Kasus anemia di Indonesia masih cukup tinggi hasil menunjukkan bahwa angka prevalensi anemia secara nasional pada semua kelompok umur adalah 21,70 %. Sedangkan prevalensi anemia di Provinsi Jawa Timur sebesar 5,8 %. Anemia adalah kondisi penyakit dimana jumlah sel darah merah lebih rendah dari jumlah normal. Kondisi ini biasa disebut sebagai kekurangan darah. Anemia dapat dideteksi dengan melakukan pengukuran kadar hemoglobin (Hb) menggunakan metode POCT (Point of Care Testing). Metode POCT merupakan metode yang dilakukan untuk pemeriksaan sederhana dengan menggunakan sampel dalam jumlah sedikit, mudah, cepat serta efektif dilakukan di daerah-daerah dengan jumlah fasilitas kesehatan seperti pusat kesehatan masyarakat (puskesmas), rumah sakit yang relatif sedikit khususnya di lokasi pengabdian masyarakat di Desa Sumbersono, Mojokerto. Jenis metode yang digunakan adalah observasional analitik. Pengabdian masyarakat ini bertujuan untuk skrining (pemeriksaan) kadar hemoglobin sebagai deteksi dini penyakit anemia dengan metode POCT, mengetahui hubungan antara umur, pendidikan, pekerjaan terhadap kejadian anemia serta sebagai upaya preventif (pencegahan) untuk meminimalisir penyakit anemia. Hasil menunjukkan dari 48 reponden (laki-laki 11 orang), (perempuan 37 orang) bahwa kejadian anemia pada perempuan 40 % lebih besar dibandingkan dengan laki-laki 6 %. Jumlah  kasus anemia terbanyak terjadi pada umur ≥ 60 presentase 36,36 % dibandingkan kelompok umur lainnya. Jumlah kejadian anemia terbanyak dengan presentase 46 % pekerjaan Petani dibandingkan pekerjaan lainnya. Jumlah anemia dengan pendidikan sekolah dasar presentase 16,67 % terbanyak dibandingkan dengan pendidikan lainnya. Kesimpulannya tidak terdapat hubungan antara umur, pendidikan, pekerjaan terhadap penyakit anemia bagi masyarakat desa Sumbersono, Mojokerto.Kata kunci: Anemia, Kadar Hemoglobin . POCT, Faktor AnemiaAbstract Cases of anemia in Indonesia are still quite high. The results show that the national prevalence of anemia in all age group is 21.70%. While the prevalence of anemia in East Java Province was 5.8%. Anemia is a disease because the number of red blood cells is lower than the normal number. This condition is commonly referred to blood deficiency. Anemia can be detected by measuring of hemoglobin (Hb) levels using the POCT (Point of Care Testing) method. The POCT method is a method that is carried out for a simple examination using a small samples, easy, fast and effective carried out in areas with a number of health facilities such as community health centers, hospitals that are relatively small, especially in community service locations in the village Sumbersono, Mojokerto. The type of method used is analytic observational. This community service activities aims to screening (examining) hemoglobin levels as an early detection of anemia using the POCT method, to find out the relationship between age, education, work and anemic events and as a preventive measure (prevention) to minimize anemia. The results showed there were 48 population, while (11 men), (37 women) that the incidence of anemia in women was 40% greater than 6% men. The highest number of anemia cases occurred at age ≥ 60 is 36.36% compared to other age groups. The highest number of anemia occurrences with 46% of Farmers' work compared to other occupations. The highest number of anemia with primary school education level is 16.67% compared to other education levels. Conclution There was no significant correlation between age, educational background, works and anemia cases in community the Sumbersono village, Mojokerto.

The fatty acid methyl ester (FAME) production from Chlorella vulgaris has been studied by sequential investigation such as microalgae culturing, lipid extraction, and lipid conversion to FAME. The C. vulgaris could grow well in the BG-11 medium and had a doubling time 3.7 days for its growth using inocula 16% (v/v). The optimum of dry cell biomass as 11.6 g/L was obtained after the microalgae culture harvested for 6 days. Lipid extraction from the biomass was carried out in various solvents and ultrasonication power, resulted lipid as 31% (w/w) when extracted with a mixed solvent of n-hexane-ethanol in ratio 1:1 and ultrasonication treatment at power 25 kHz/270W for 30 min. The lipid then converted to FAME through transesterification reaction with methanol using H2SO4 catalyst at 45ºC for 2 h, and resulted FAME with area 32.26% in GC-MS analysis. The area was corresponded to FAME output as 13.68% (w/w). Fatty acid profiles of FAME obtained from GC-MS analysis showed the major peaks of fatty acids found in Chlorella vulgaris were palmitic acid (C16:0), stearic acid (C18:0) and margaric acid (C17:0), and nonadecanoic acid (C19:0). Optimization of the transesterification reaction will be developed in future to improve the FAME product.

The prevalence of cancer in Indonesia has increased by 8.8 percent in the last two years (2018 and 2020) in terms of adding new cases and mortality. Because of therefor cancer treatment becomes important in reducing the high number of additional new cases and mortality due to cancer patients. Intensive cancer treatment is by surgery, chemotherapy, radiotherapy and immunotherapy. Chemotherapy drugs used for cancer treatment include herbal plant-based cancer drugs (Cancer Fit) and cisplatin its buy from online shop. This study aims to compare the toxicity of herbal drugs (Cancer fit) with cisplatin, a combination of BSA nanoparticles and folic acid as anticancer candidates. The research method is through the synthesis of nanoparticles with the desolvation method, then characterization is carried out using XRD and FT-IR tests. After that proceed to the toxicity test with the BSLT method. The results obtained from XRD analysis on BSA and folic acid nanoparticles from cisplatin (As-NP-BSA-CP) showed a peak of 34.45 while BSA and folic acid nanoparticles from herbal medicine (As-NP-BSA-Oh) obtained a peak of 22.77. The purpose of XRD analysis was to determine the crystalline characteristics of the synthesized nanoparticles and to analyze the crystalline index. FT-IR analysis on (As-NP-BSA-CP) showed that there are functional groups O-H alcohol, C-H, C-C, NO2 that play a role in the synthesis of nanoparticles. Meanwhile, (As-NP-BSA-Oh) showed that the functional groups were C-H alkene, C-O alcohol, and C-N amine/amide. The toxicity level of As-NP-BSA-CP LC50 is 69.14 ppm while the toxicity level of As-NP-BSA-Oh LC50 is 44.14 ppm. Nanoparticles consisting of a combination of bovine serum albumin (BSA), folic acid and cisplatin drugs or herbal drugs can be used as candidates for anticancer drugs.

<p>Kanker adalah penyakit tidak menular yang menyebabkan morbiditas dan mortalitas di seluruh wilayah dunia. Salah satu pengobatan kanker adalah dengan menggunakan obat kemoterapi cisplatin. Namun cisplatin memiliki efek samping yang bersifat toksik jika dikonsumsi dalam dosis dan waktu tertentu. Kombinasi nanopartikel <em>bovine serum albumin </em>(BSA) yang mengandung cisplatin dikembangkan dengan modifikasi ikatan menggunakan asam folat sebagai solusi alternatif meminimalisir efek toksik yang dihasilkan dan mengoptimalkan sistem pengiriman obat. Tujuan penelitian adalah sintesis kombinasi nanopartikel BSA yang mengandung cisplatin dan modifikasi ikatan menggunakan asam folat sebagai kandidat antikanker. Penelitian ini dilakukan melalui sintesis dengan metode desolvasi. Hasil penelitian menunjukkan bahwa nanopartikel BSA yang dikombinasi dengan cisplatin dan asam folat telah berhasil disintesis. Analisis FT-IR menunjukkan bahwa ada gugus fungsi O-H alkohol, C-H, C-C, NO₂ yang berperan dalam sintesis nanopartikel. Analisis XRD menunjukkan adanya pergeseran <em>peak</em> dari NP-BSA 31,69 menjadi As-CP-NP-BSA 34,45; ukuran nanopartikel NP-BSA 2,38 nm dan As-CP-NP-BSA 2,62 nm sedangkan analisis SEM-EDX diketahui ada unsur C, O, Mg, Cl dan Pt.</p>

Collagen gives a moist state on the wound area to accelerate the wound healing process. Chitosan is a polymer as known as non-toxic, antibacterial, antifungal, biodegradable, and biocompatible materials. Combination of collagen and chitosan expected to be the  best biomaterials as a wound dressing for the healing process. The study aimed to determine cytotoxicity assay on collagen-chitosan wound dressing  sterilized by ultraviolet (UV) Light using Brine Shrimp Lethality Test (BSLT) method. The test groups were divided into  K0, K1, K2, and K3 groups. K0 contained pure chitosan as a control group, K1 contained collagen 25%-chitosan 75%, K2 contained collagen 50%-chitosan 50%, K3 contained  collagen 75%-Chitosan 25%. Collagen extracted from skin and scalp of snakehead fish (Channa striata) then mixed with chitosan until formed collagen-chitosan wound dressing. This study used Brine Shrimp Level Test (BSLT) method with solution concentration 10, 50, 100, 250, 500, 750 and 1000 ppm. Based on the results showed that K0, K1, K2, and K3 group had LC50 > 1000 that proven collagen-chitosan wound dressing was non-toxic materials. As conclusion of the study explained composite wound dressing based on collagen-chitosan in all groups that sterilized under UV-Light along 15 minutes was not toxic based on Brine Shrimp Lethality Test showed LC50> 1000.