No abstract

Carbon dots (CDs), as rapidly developing nanomaterials, give new prospects for the treatment of various diseases. Their great biocompatibility and wide specific surface area make CDs excellent drug-delivery vehicles because they improve cellular uptake and absorption and allow for medications to bind more easily. CDs offer enormous potential as delivery systems for antiinflammatory medications. The activities of antiinflammatory drugs delivered by CDs are higher than those of free drugs. They also have controlled release, thus enhancing the cumulative effect at the inflammation site and improving pharmacokinetics. Compared with free small-molecule antibacterial medicines, CD-based drugdelivery systems have higher antibacterial efficacies, better targeting, increased cellular uptake and internalization efficiency, and decreased systemic side effects. The benefits of using CDs as anticancer drug carriers include high drug loading, increased targeting, lower drug dosage, regulated drug release, and synergistic photothermal therapy, which offers a novel approach to the diagnosis and treatment of cancer in clinical settings. However, it is important to consider the biosafety, toxicity, and impact of CDs on the immune system of an organism before using them as drug-delivery vehicles for clinical diagnosis and therapy. This review discusses the use of CDs in the delivery of antiinflammatory, antibacterial, and anticancer drugs and summarizes the current advantages and challenges of using CDs for drug delivery.

Carbon dots (CDs) are novel zero-dimensional spherical nanoparticles with water solubility, biocompatibility and photoluminescence properties. As the variety of raw materials for carbon dots synthesis becomes more and more abundant, people tend to choose precursors from nature. Many recent studies have shown that CDs can inherit properties similar to their carbon sources. Chinese herbal medicine has a variety of therapeutic effects to many diseases. In recent years, many literatures have chosen herbal medicine as raw materials, however, how the properties of raw materials affect CDs has not been systematically summarized. The intrinsic bioactivity and potential pharmacological effects of CDs have not received sufficient attention and have become a "blind spot" for research. In this paper, the main synthesis methods were introduced and the effects of carbon sources from different herbal medicine on the properties of CDs and related applications were reviewed. In addition, we briefly review some of the biosafety assessments of CDs and make recommendations for biomedical applications. CDs that inherit the therapeutic properties of herbs can enable diagnosis and treatment of clinical diseases, bioimaging, and biosensing in the future.