Resumo: A hepatite C é uma inflamação hepática que, de acordo com a Organização Mundial da Saúde, atinge cerca de 130 milhões de pessoas. Ela pode estar relacionada a diversos fatores, como o uso de alguns fármacos, a intoxicação por agroquímicos e a contaminação por agentes infecciosos. A sintomatologia, em sua maioria, é crônica; por isso, em muitos casos, leva anos para manifestar os sintomas. Portanto, normalmente muitas pessoas são infectadas mas não sabem, visto que a identificação dos sintomas é decorrente de um longo período. Objetivo: Elucidar o impacto da Hepatite C na qualidade de vida de pacientes usuários de drogas. Metodologia: Trata-se de uma revisão bibliográfica com base em artigos disponíveis nas bases de dados SciELO, LILACS e PubMed. Os descritores empregados na busca foram: hepatite C, abuso de substâncias por via intravenosa, vírus da hepatite, uso comum de agulhas e seringas, genótipo do HCV, virologia do HCV e seus correspondentes em inglês. Os critérios de inclusão foram: estudos empíricos sobre o alto risco de infecção em usuários de drogas e estudos voltados para os problemas psicológicos e sociais; e o de exclusão: artigos direcionados para outros tipos de hepatite. Ademais, apenas artigos publicados a partir do ano 2000 foram relevantes para a extração de dados. Foram encontrados 1.144 artigos. Desse total, foram apurados 31 com base nos critérios de inclusão e exclusão. Discussão: A partir dos dados encontrados, analisou-se que a Hepatite C não possui a mesma atenção social que é voltada para outras doenças, como o HIV. Além disso, foi revelado o baixo nível de conhecimentos das pessoas a respeito dessa doença. Conclusão: Com as análises, pode-se perceber a alta prevalência do vírus da hepatite C em usuários de drogas injetáveis e as consequências da manifestação silenciosa da doença seguidas pelas dificuldades de lidar com o diagnóstico -transtornos mentais e sociais.Palavras-chave Hepatite C, Drogas injetáveis, Usuários de drogas, Vulnerabilidade social. Hepatitis C: Risks and Consequences in Drug UsersAbstract: Hepatitis C is a hepatic inflammation that, according to the World Health Organization, reaches about 130 million people. It may be related to several factors, such as the use of some drugs, agrochemical intoxication and contamination by infectious agents. Symptomatology, for the most part, is chronic; so in many cases it takes years to manifest the symptoms. Therefore, many people are usually infected but do not know, since the identification of the symptoms is due to a long period. Objective: To elucidate the impact of Hepatitis C on the quality of life of drug users. Methodology: This is a bibliographic review based on articles available in the SciELO, LILACS and PubMed databases. The descriptors used in the search were: hepatitis C, intravenous substance abuse, hepatitis virus, common use of needles and syringes, HCV genotype, HCV virology and their correspondents in English. The inclusion criteria were: empirical studies on the high risk of infection in drug users and...

Na maioria dos municípios brasileiros, existem depósitos sem nenhum tipo de controle ou cuidado ambiental, chamados de vazadouros a céu aberto – os lixões. Neste cenário, a incineração irregular e as queimadas clandestinas dos resíduos sólidos domésticos produzem gases ricos em substâncias potencialmente tóxicas. Esta revisão buscou na literatura os principais gases tóxicos e suas manifestações clínicas associadas. Após a combustão dos resíduos domésticos, uma grande quantidade de gases e partículas sólidas são liberados na atmosfera, a exemplo do monóxido de carbono (CO), metano (CH4), hidrocarbonetos leves, compostos orgânicos voláteis (COV), orgânicos semi-voláteis (COSV), hidrocarbonetos aromáticos policíclicos (HAP), chumbo (Pb), mercúrio (Hg), dibenzenodioxinas-policlorados (PCDDs), dibenzofuranos-policlorados (PCDFs) e os bifenilos-policlorados (PCBs). Tais componentes estão associados a algumas manifestações clínicas respiratórias, reprodutivas e oncogênicas com elevado impacto na saúde da população. Dessa forma, para entender os efeitos diretos e indiretos do destino inadequado dos resíduos sólidos e suas consequências é imprescindível mais investimentos e projetos para criação de aterros sanitários controlados e mais estudos relacionados à temática.

Postpartum depression can reach up to 15% of pregnant women in developed countries, 25% in underdeveloped countries and up to 40% throughout the perinatal period. Depressive mothers interact less with their children, they show less love and affection, and this may have an impact on the lives of these infants in the future. Babies who lived in this context had problems with language acquisition, cognitive impairment, delay in achieving developmental milestones, attachment insecure, low self-esteem. It is essential that the diagnosis of depression be made as early as possible so that therapeutic and preventive measures are implemented in a timely manner in order to provide healthy child growth and ensure the good mental health of these mothers.Keywords: Postpartum depression; childish behaviour; mother-child relationship; diagnosis; pharmacological treatment; combination therapy;

INTRODUCTION: Realistic simulation is increasingly present in academic curricula. The traditional method of teaching is being gradually replaced by new methodological approaches, which reliably reproduce real situations and produce technical knowledge and skills in medical students in the medical emergency.Realistic simulation is increasingly present in the academic curriculum. The traditional method of teaching is being gradually replaced by new methodological approaches, which reliably reproduce real situations and produce technical knowledge and skills in medical students in the medical emergency. The aim of this study was to carry out a systematic review of articles on realistic simulation as an educational tool in emergency medicine. A systematic review of articles on realistic simulation as an educational tool in emergency medicine, published in the corresponding period from January 1th, 2014 to October 28, 2018, was carried out in the SCOPUS database. The keywords were "simulation training", "medical students" and "emergency medicine". The research strategy resulted in 124 references. After the search for the title and summary of the citations considered for eligibility based on the inclusion criteria of the study, 106 articles were excluded, and 18 articles were retrieved and included in the final sample. The studies were distributed in 5 categories to better systematic review of the organizational quality, they are: Realistic simulation associated with the ultrasonography in the emergency; Realistic simulation and electronic devices; The effectiveness of realistic simulation in resource optimization; Impact of simulated training on student confidence; Realistic simulation as a tool in the development of skills and knowledge. This study presents the main aspects of realistic simulation as an educational tool in emergency medicine. It can be concluded that this new teaching approach has several benefits for students to learn, such as: stimulating students in the learning process, retaining technical skills in procedures, providing a safe environment for users to repeat optimization of time and financial resources.Keywords: realistic simulation, emergency medicine, educational, systematic review

Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were "Genetic markers", "Mutation", and "Schizophrenia". Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene. KeywordsSchizophrenia, Genetic Markers, Mutations, Systematic Review How to cite this paper: Cardoso, M.A.B.S., do Nascimento, T