Anemia merupakan masalah gizi yang paling sering dijumpai di dunia. Berdasarkan Laporan Nasional Riskesdas 2018, angka kejadian anemia pada remaja usia 15-24 tahun sebesar 32%. Angka ini termasuk tinggi untuk masalah kesehatan yang terkait gizi pada remaja. Masa remaja merupakan masa pertumbuhan yang membutuhkan asupan gizi tinggi, baik berupa energi, protein dan zat-zat gizi lainnya dan kebutuhan zat besi meningkat pada remaja dapat menyebabkan anemia pada remaja. Tujuan dari kegiatan pengabdian ini adalah untuk mencegah penyakit anemia dengan pemeriksaan hemoglobin awal pada santri Pondok Pesantren (Ponpes) Thawalib Sriwijaya Palembang. Sasaran pengabdian ini adalah santri-santri pondok pesantren berusia 12-18 tahun, sebanyak 46 orang. Kegiatan dilakukan dalam bentuk ceramah tentang anemia, diskusi dan pemeriksaan kadar hemoglobin. Dari hasil pemeriksaan didapatkan bahwa 14 santri (30%) yang memiliki gejala anemia karena kadar hemoglobin kurang dari normal, yaitu 13 santri laki-laki yang memiliki kadar hemoglobin

Background. Breast cancer is one of the four types of cancer among women and is the most frequently diagnosed in most countries. Breast cancer occurs due to DNA damage and genetic mutations affected by exposure to estrogen, inheritance of damaged DNA, or pro-cancer genes such as BRCA1 and BRCA2. Therefore, a family history of ovarian cancer or breast cancer increases the risk of developing breast cancer. The embryo of the breast develops around the age of 6 weeks of pregnancy. Similar to breast development, fingerprint patterns also develop during the 6-13 weeks of pregnancy. Thus, the genetic message contained in the genome occurred during that period and was reflected in the dermatoglyphic pattern.Methods. The literature search was systematically used using PubMed, Cochran, Google scholar, and other Gray literature between 2010-2020. Of the 69 publications identified, 21 met the criteria and were included in the review. The review is carried out following the provisions of PRISMA (Preferred Reporting Items for Systematic Review).Results. This systematic review showed fairly consistent findings in breast cancer patients who tended to have more whorl fingerprint patterns and larger ATD angles. For radial loops, ulnar loops and arches were minor compared to the control group potential as an initial screening tool in at-risk groups.Conclusion. Long-term and follow-up studies with larger sample sizes in various ethnicities are needed to validate dermatoglyphics in anthropometric measurements as a promising marker of breast cancer.

Indonesia has a variety of plants that have the potential for medicine. One of the plants used by the community as a drug with anticancer effects is Dendrophtoe petandra (L.) Miq. This study aims to determine the cytotoxic effect of ethanol extract, ethyl acetate fraction and water ethanol fraction of Dendrophtoe petandra (L.) Miq on T47D breast cancer cells. The cytotoxic effects of ethanol extract, ethyl acetate fraction and water ethanol fraction were carried out by MTT assay method using series concentration. Cytotoxic effects were assessed by calculating IC50 values using linear equations. Phytochemical test showed that Dendrophtoe petandra (L.) Miq contained saponins, terpenoids, flavonoids and tannins. The IC50 value of the ethanol extract, ethyl acetate fraction and water ethanol fraction were 417.506 μg/mL, 233.617 μg/mL, and 2748.357 μg/mL, respectively. The smaller the IC50 value means that the compound is more active. Water ethanol fraction of Dendrophtoe petandra (L.) Miq does not have a cytotoxic effect, whereas ethanol extract and ethyl acetate fraction of Dendrophtoe petandra (L.) Miq have cytotoxic effects in the medium strength category. The content of flavonoids and saponins in ethanol extract and ethyl acetate fraction of Dendrophtoe petandra (L.) Miq is thought to play role in causing T47D cell death. Cytotoxic effects of ethyl acetate fraction are stronger than ethanol extracts.

Breast cancer is one of the biggest causes of death in women in the world. Lime parasite (Dendrophtoe pentandra (L.) Miq.), a folk remedy used by Indonesian people, is believed to be efficacious as anticancer drug. This research aims to know the activity of n-hexane fractions of lime parasite in inhibiting the proliferation and apoptosis of T47D cells in vitro. Cytotoxic test with MTT method assay from n-hexane fractions used a multilevel concentration. Antiproliferative test was carried out by the method of MTT assay and cell doubling time was calculated at the time of duplication. Apoptotic test was done with concentration of 1 IC50and ½ IC50which was analyzed by flow cytometry. The results reveals that fractions of lime parasite have cytotoxic activity with concentration of IC50is included in moderatecytotoxic level. The result of the doubling time of the optimum fraction of n-hexane is in 31 hours with the concentration of ¼IC50. Results for the flow cytometry shows the fraction of n-hexane does not induce apoptosis in cells of T47D.  Those results show that the active fraction of lime parasite has cytotoxic activity which is able to inhibit proliferation, but does not induce apoptosis of T47D cell.

Gaya hidup sehat menjadi hal penting yang perlu diperhatikan dan dijadikan prinsip dalam menjaga derajat kesehatan. Namun, kesibukan harian dalam memenuhi membuat masyarakat kurang memperhatikan diet dan pola aktivitas fisik yang baik dan benar, sehingga berpotensi menimbulkan penyakit yang dapat dinilai salah satunya melalui total leukosit. Penelitian ini bertujuan untuk menganalisis respon akut total leukosit tikus putih (Rattus norvegicus) pada variasi diet vegetarian pada olahraga berat. Metode penelitian berupa eksperimental in vitro melalui pendekatan eksploratif analitik dengan menggunakan desian pre-posttest design with nonequivalent groups. Penelitian ini menggunakan hewan coba tikus putih (Rattus norvegicus) sebagai sampel dengan pemberian tiga tipe diet vegetarian dan diet standar. Pengukuran total leukosit dilakukan sebelum dan sesudah perlakuan olahraga berat berupa berenang hingga lelah. Data setiap kelompok dianalisis secara statistik menggunakan uji-t. Hasil menunjukkan bahwa terdapat perubahan signifikan total leukosit pasca olahraga berat pada kelompok diet vegetarian tipe quasi p=0,028 (p<0,05), lacto-ovo p=0,007 (p<0,05) dan diet standar p=0,045 (p<0,05), sedangkan diet vegetraian tipe vegan tidak menunjukkan perubahan total leukosit yang signifikan pasca olahraga berat p=0,752 (p<0,05). Kesimpulannya, perubahan respon akut total leukosit tikus putih pasca olahraga berat terjadi pada diet vegetarian tipe quasi dan lacto-ovo.