Introdução: tecnologias digitais como as gamificações vem modernizando e inovando o processo de aprendizagem. Objetivo: agrupar, por meio de uma revisão de literatura, evidências científicas acerca da aplicabilidade do Kahoot© como estratégiade aprendizagem na disciplina de Ciências Morfofuncionais. Metodologia: os termos “anatomy”, “histology”, “embryology”, “gamification”, “kahoot”, “Kahoot!”, foram empregados nas bases de dados PubMed, Scopus, Bireme, Web of Science, Science Direct e Eric, utilizando operadores booleanos OR/AND. Foram estabelecidos como critérios de inclusão, artigos com delineamento do tipo experimental, observacional e revisões sistemáticas que descreveram a utilização do Kahoot© como ferramenta de ensino na disciplina de morfologia humana, publicados nos idiomas inglês, espanhol e português, no período de 2013 a 2021. Foram excluídos, artigos que utilizaram o Kahoot© em outras áreas do conhecimento e em outros componentes curriculares. Resultados: a amostra foi constituída por 337 artigos que, após leitura do título e resumo, foram submetidos aos critérios de inclusão e exclusão. Destes,11 artigos foram elegíveis para o estudo. Discussão: o Kahoot© motiva o estudante, criando uma atmosfera divertida, favorecendo o trabalho colaborativo e o engajamento dos alunos em seu processo de aprendizagem. Elementos associados à gamificação foram vistos como responsáveis pela descontração e como agentes estressores. Conclusão: o Kahoot© possibilita um aprender divertido e dinâmico, porém, pesquisas que utilizem grupo controle e experimental são relevantes para verificar a efetividade do Kahoot© no ensino de morfologia a curto, médio ou longo prazo, potencializando os benefícios do seu uso em sala de aula.
The present study aims to evaluate the accuracy of the prognostic discrimination and prediction of the short-term mortality of the Marshall computed tomography (CT) classification and Rotterdam and Helsinki CT scores in a cohort of TBI patients from a low- to middle-income country. This is a post hoc analysis of a previously conducted prospective cohort study conducted in a university-associated, tertiary-level hospital that serves a population of >12 million in Brazil. Marshall CT class, Rotterdam and Helsinki scores, and their components were evaluated in the prediction of 14-day and in-hospital mortality using Nagelkerk's pseudo- R 2 and area under the receiver operating characteristic curve. Multi-variate regression was performed using known outcome predictors (age, Glasgow Coma Scale, pupil response, hypoxia, hypotension, and hemoglobin values) to evaluate the increase in variance explained when adding each of the CT classification systems. Four hundred forty-seven patients were included. Mean age of the patient cohort was 40 (standard deviation, 17.83) years, and 85.5% were male. Marshall CT class was the least accurate model, showing pseudo- R 2 values equal to 0.122 for 14-day mortality and 0.057 for in-hospital mortality, whereas Rotterdam CT scores were 0.245 and 0.194 and Helsinki CT scores were 0.264 and 0.229. The AUC confirms the best prediction of the Rotterdam and Helsinki CT scores regarding the Marshall CT class, which presented greater discriminative ability. When associated with known outcome predictors, Marshall CT class and Rotterdam and Helsinki CT scores showed an increase in the explained variance of 2%, 13.4%, and 21.6%, respectively. In this study, Rotterdam and Helsinki scores were more accurate models in predicting short-term mortality. The study denotes a contribution to the process of external validation of the scores and may collaborate with the best risk stratification for patients with this important pathology.
Resumo: O dbjehovd /eshe hoabalhd fdo todmdveo a a/sdoçãd /a Strychnos pseudoquina STx HILL (Quona /d Ceooa/d) em mocodesfeoas /e PEG e avaloao seu efeohd omundmd/ula/do sdboe a ahovo/a/e funcodnal /e farócohds /e sanrue humandx Fdoam cdleha/as 120 amdshoas /e sanrue humand taoa dbhençãd /ds farócohdsx O edhoahd aqudsd /a tlanha fdo dbho/d tdo maceoaçãd seruo/a /e /esholaçãdx As mocodesfeoas /e tdloeholendrlocdl fdoam analosa/as tdo mocodscdtoa /e fludoescêncoa, tdo cohdmehooa /e fludd e tdo estechodscdtoa nd onfoaveomelhd e a ahovo/a/e funcodnal /ds farócohds fdo veoofica/a ahoavés /a lobeoaçãd /e suteoódo/d, /a fardcohdse e /a ahovo/a/e mocodboco/ax As análoses /e mocodscdtoa /e fludoescêncoa e /e cohdmehooa /e fludd oevelaoam que as mocodesfeoas /e PEG atoesenhaoam um hamanhd atoddoma/d /e 5,8 µm e que d edhoahd /a "Quona /d Ceooa/d" e suas foações fdoam catazes /e a/sdoveoem às mocodesfeoas /e PEGx A a/sdoçãd /a quona e /e suas foações às mocodesfeoas /e PEG aumenhdu a ahovo/a/e funcodnal /ds farócohdsx Eshes /a/ds teomohem cdncluoo que a a/sdoçãd /d edhoahd /e Strychnos pseudoquina STx HILLx em mocodesfeoas /e PEG td/e seo um omtdohanhe nedmaheooal funcodnal taoa fuhuoas atlocações clínocas em /denças onflamahóooas e coônocas /ereneoahovasx Palavras-chave: Fagócitos, polietilenoglicol, strychnos pseudoquina ST. HILL., microesferas. Immunomodulation of Human Blood Phagocytes by Strychnos Pseudoquina ST. HILL Adsorbed to Polyethylene Glycol (PEG)Abstract: The aom df hhos shu/y was hd evaluahe hhe a/sdothodn df Strychnos pseudoquina STx HILLx ("Quona /d Ceooa/d") dnhd PEG mocodstheoes an/ hd veoofy hhe ommundmd/ulahdoy effech dn bldd/ thardcyhesx 120 bldd/ samtles fodm humans weoe use/ hd dbhaon hhe thardcyhesx Poetaoahodn df tlanh edhoach df Strychnos pseudoquina STx HILLx was caoooe/ duh by maceoahodn fdlldwe/ by /oshollahodnx The PEG mocodstheoes weoe analyze/ by fludoescence mocodscdty, fldw cyhdmehoy an/ onfoaoe/ stechoum, whole hhe funchodnal achovohy df thardcyhes was measuoe/ by hhe oelease df suteoddo/e, thardcyhdsos an/ mocodboco/al achovohy df bldd/ thardcyhesx The analysos df fludoescence mocodscdty an/ fldw cyhdmehoy oeveale/ hhah hhe PEG mocodstheoe ha/ attoddomahely 5x8 µm on soze an/ hhah "Quona /d Ceooa/d" an/ ohs foachodns weoe able hd absdob dnhd PEG mocodstheoesx The a/sdothodn df hhe tlanh an/ ohs foachodns hd hhe PEG mocodstheoes oncoease/ hhe funchodnal achovohy df thardcyhesx These /aha shdw hhah hhe a/sdothodn df hhe edhoach df Strychnos pseudoquina STx HILLx dn PEG mocodstheoes can be an omtdohanh funchodnal new maheooal fdo fuhuoe clonocal attlocahodns on onflammahdoy an/ chodnoc /ereneoahove /oseasesx Keywords: Phagocytes, polyethylene glycol, strychnos pseudoquina ST. HILL., microspheres. IntroduçãoPdlímeods sãd mdléculas nahuoaos du sonhéhocas caoacheooza/as tela oetehoçãd múlhotla /e uma du maos estécoes /e áhdmds du routds /e áhdmds lora/ds uns ads duhods em quanho/a/es suficoenhes taoa fdoneceo um cdnjunhd /e todtooe/a/es que nãd vaooam acenhua/amenhe cdm a a/oçãd du oemdçãd /e...
BackgroundIn this study, we produced poly(ethylene glycol) (PEG) microspheres of different sizes and adsorbing a medicinal plant mixture, and verified their effect in vitro on the viability, superoxide production, and bactericidal activity of phagocytes in the blood.MethodsThe medicinal plant mixture was adsorbed onto PEG microspheres and its effects were evaluated by flow cytometry and fluorescence microscopy.ResultsAdsorption of the herbal mixture onto the PEG microspheres was achieved and the particles were internalized by phagocytes. PEG microspheres bearing the adsorbed herbal mixture stimulated superoxide release, and activated scavenging and microbicidal activity in phagocytes. No differences in functional activity were observed when the phagocytes were not incubated with PEG microspheres bearing the adsorbed herbal mixture.ConclusionThis system may be useful for the delivery of a variety of medicinal plants and can confer additional protection against infection. The data reported here suggest that a polymer adsorbed with a natural product is a treatment alternative for enhancing immune function.
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