The examination of the possibility of using immunohistochemical and molecular genetic markers as predictors of effectiveness of neoadjuvant chemoradiotherapy (NCRT) and prognostic factors of the disease state. The study included 21 patients with locally advanced gastric cancer. All patients underwent the NCRT followed by gastrectomy D2. We analyzed the expression of HER2 / neu marker, Ki-67, p53, Cyklin D1, E-cadherin in biopsy (before therapy) and the operating material (after chemoradiotherapy and the treatment gap). We have found statistically significant decrease in the expression of Ki-67 markers and Cyklin D1, a trend towards to a decrease of p53 expression after the NCRT. The dynamics of expression of immunohistochemical markers examination is a promising approach in search for predictors of NCRT effectiveness for patients with locally advanced gastric cancer.

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At present, as a result of the expansion of the use of the development of information and computer technologies, the increase in the situation of uncertainty in various spheres of a person's life (social, economic, professional), the problem of the formation and development of future specialists, which is directly related to their readiness for professional activity, is becoming more and more urgent. The purpose of this study was to identify and analyze differences in the structure of psychological readiness for professional activity among students at different stages of study at a university. The study involved students of the Faculty of Law of The Herzen State Pedagogical University of Russia (St. Petersburg) in the amount of 107 people. To study the components of psychological readiness were used: the technique "Who am I?" M. Kuhn and T. McPartland (translated and adapted by T.V. Rumyantseva), S. Schwartz’s method for studying personality values, R. Cattell’s method of multifactorial personality research (187), method of studying professional identity statuses (A.A. Azbel, A.G. Gretsov) and the methodology for diagnosing the socio-psychological attitudes of the individual in the motivational-demand sphere of O.F. Potemkina. The following methods were used to process the data obtained in the study: descriptive statistics, comparative statistics (parametric statistical tests of Student's t-test and non-parametric statistical test of U-Mann Whitney). Mathematical data processing was carried out using the Statistica package (Version 10). The study found that students of the 1st and 4th courses have the most pronounced socio-psychological attitudes “Orientation to freedom”, “Orientation to the process” and “Orientation to the result”, statistically significant differences were found only in the indicator “Orientation to the result”. The subjects are characterized by a similar personality profile, and statistically significant differences between the samples were established only for the indicator G - moral normativity. In the student environment, values that reflect personal success are more important than the interests of the group. Statistically significant differences were found only in the "Conformity" indicator. In the study of the cognitive component, it was found that the largest number of self-descriptions refer to the personal identity of students of both courses, to personal qualities, character traits, to an individual style of behavior ( "Reflexive Self").

The article presents the scheme and principle of operation of a combined fluidized bed unit with re-utilization of heat from exhaust gases of a diesel generator and indicates the requirements for the functioning and operation of these types of installations. It presents theoretical and experimental graphs of the required volumes of air replacement with diesel exhaust gases in nominal and fractional modes, fuel economy, transients of changes in the fluidized bed temperature from time to time when various disturbing effects are applied.

Professions aimed at helping and supporting a person in a difficult situation, with their traditions and principles of assisting activities, have existed since ancient times. The main purpose of the helping professions is to improve the quality of life of the person who sought help and to activate his inner potential. The importance of existential problems and their solution in the way of the professions plays a special role, since only a harmonious person who has reached agreement with himself and the outside world can fully open up in the profession. Despite the individual specifics of each profession; regardless of the direction of his work, the helper must have not only a certain set of personal qualities and a proper level of professional knowledge, but also an understanding, awareness and acceptance of the level of responsibility that he bears for what is happening in the work process. The study describes the relationship of future aid specialists to existential problems, professional responsibility and future profession.