No abstract

<!-- /* Font Definitions */ @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;} @font-face {font-family:"Calibri Light"; panose-1:2 15 3 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:-1610611985 1073750139 0 0 415 0;} @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:-536870145 1073786111 1 0 415 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin-top:0cm; margin-right:0cm; margin-bottom:6.0pt; margin-left:0cm; text-align:justify; text-indent:21.25pt; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri Light"; mso-ascii-font-family:"Calibri Light"; mso-ascii-theme-font:major-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:"Calibri Light"; mso-hansi-theme-font:major-latin; mso-bidi-font-family:"Calibri Light"; mso-bidi-theme-font:major-latin; mso-ansi-language:EN-GB;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:11.0pt; mso-ansi-font-size:11.0pt; mso-bidi-font-size:11.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:FR;} .MsoPapDefault {mso-style-type:export-only; margin-bottom:8.0pt; line-height:107%;} @page WordSection1 {size:612.0pt 792.0pt; margin:72.0pt 72.0pt 72.0pt 72.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.WordSection1 {page:WordSection1;} --> Collected by honeybees, Bee pollen is a flower pollen gathered from selected flower species by special pollen traps, therapeutic qualities and reproductive performance of bee pollen are given from biologically active substances. Lead is a heavy metal, which induce reproductive intoxication, comes in the high levels from human activities.The aim of the present study was to evaluate the impact of bee pollen hydro-ethanolic extract on adult Wistar rat testis exposed to lead acetate sub-acute intoxication (15 days), highlighted using histological technics in situ. The biochemical and biometric measurement were conducted to verify any eventual toxicity of hydro-ethanolic extract in vivo. Animals were divided into four equal groups: first control group was treated orally with distillated water (1 ml) by gavage. The second group was administered 100 mg/kg/bw/day of a hydro-ethanolic extract of bee pollen, the third group was administered 30 mg/kg/bw/day lead acetate, the fourth group was given the both treatments in the same levels. The results showed that the relative organs weight indicates that only left kidney (p=0.001) and spleen (p=0.001) were attenuated without a considerable difference of the liver (p=0.07). the same was shown for relative weight of sexual organs. In addition, no significant difference, was marked, in serum biochemical parameters except for: Blood urea nitrogen, Alanine aminotransferase, Total bilirubin and Direct bilirubin. furthermore, ameliorative effect was shown after lead-induced alteration after histological stain of seminiferous tubules, indicating low lumen of seminiferous tubules with presence of spermatogonia and wide height of seminiferous epithelium. Biological activities of bee pollen extract, alleviate the lead induced toxicity on rat testis, marked by a complete spermatogenesis and prevention of Sertoli cells destruction.

Background: Inflammation is a major burning problem worldwide and billions of individuals are affected. Some of the spices used daily in Algerian cuisine have been known to possess major anti-inflammatory effects. Turmeric, red pepper, ginger, cinnamon and cumin  etc. are a few of the wide spectrum of spices used in Algeria. The aim of the study was to investigate the antiinflammatory effect  and anti actvity of some dietary spices in carrageenan induced models of inflammation on Wistar  rats. Methods: Albino wistar rats were divided into four groups. Inflammation was induced on the animal by injecting the right hand paw with carrageenan (0.1 ml of 1%). Group 1  was fed with food and water and  treated with carrageenan (control) whereas group 2 and  3 treated with different doses (100 and 200 mg/kg/bw) of aqueous extract of some dietary spices with carrageenan, respectively. Group 4  treated with standard drug diclofenac sodium (10 mg/kg b.w., reference drug for inflammation), once for 24 hrs. Results: The content of total phenolic was 137.2±21.6 mg/g and flavonoids 122.3±5.8 mg/g. After 60, 120, 180, 240 and 300 min, the data indicate that  some dietary spices 100 and 200 mg/kg was significantly effective reducing paw edema volumes induced by carrageenan compared to control (p <0.01). The levels of serum pro-inflammatory white blood cells, neutrophile, lymphocyte, monocyte,  eosinophile, total protein and protein c reactive and total cephalin KADIN  and platelts in the control group were significantly increased by carrageenan injection compared with the normal group. The rats pretreated with some spices 100 and 200 mg/kg had significantly lower levels of pro-inflammatory to compare control group. The paw edema in carrageenan-induced rats was considerably reduced by treating with 100 and 200  mg/kg aqueous extract of some dietary spices when compared to the untreated  rats (p<0.001). Conclusion : The present results clearly demonstarted that carrageenan significantly increased paw edema whereas some dietary treated rats significantly decreased the paw edema. The study underlines the importance of some of the frequently used spices (Turmeric, red pepper, ginger, cinnamon and cumin)  in the treatment of inflammation.

Celery (Apium graveolens L.) belongs to the Apiaceae family. It is a genus of an annual or biannual herb. A. graveolens is used in Algeria as a medicinal plant for the treatment of many diseases. This study was carried out to assess and confirm the in vivo anti-inflammatory and analgesic effect of hydroalcoholic extract from A. graveolens leaves. Wistar albino rats of both sexes, with different ages 2–3 months weighing between 160 and 250 g and Swiss albinosmice weighing 22–27 g were used for this study. The antiinflammatory activity was estimated by measuring the oedema induced by Carrageenan; the analgesic activity was performed by the acetic acid–induced writhing test and formalin-induced paw licking. The administration of hydroalcoholic extract at doses of 200, 300 and 500 mg/kg body weight significantly reduced the increase of the paw volume with an inhibition percentage of 80.17%, 86.50% and 89.66%, respectively; all doses showed a strong significant effect (p < 0.001). These results were similar to those obtained with piroxicam 78.93% and indometacine 76.13%. Although the same doses showed a high significant effect (p < 0.01) compared to the control group, the extract at a dose of 500 mg/kg registered higher levels of analgesic activity (17 ± 2.36) writhing (75.53% inhibition) than the standard drug paracetamol (30.5 ± 3.61) writhing; in the two tests, acetic acid induced writhing and formalin induced paw licking. The study of hydroalcoholic extract in vitro showed a high antioxidant capacity by inhibition of 2,2-diphenyl-1-picrylhydrazyl radical (IC50 = 1.29 mg/ml). In conclusion, A. graveolens is an interesting plant and the hydroalcoholic leaves extracts could be used scientifically in the treatment of acute inflammation and the peripheral analgesic activity.

No abstract