Development of highly porous, Electrostatic force assisted nanofiber fabrication for biological applications

Purushothaman, Anukrishna Eratt; Thakur, Kirti; Kandasubramanian, Balasubramanian

doi:10.1080/00914037.2019.1581197

Cited by 26 publications

(12 citation statements)

References 369 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depending on the humidity, fiber morphology can vary from ribbons to cylindrical fibers. Further increases in humidity level can result in solvent evaporation, which may induce some fibers to stick to each other on the collector [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Electrospun Collagen Based Composites for Biomedical Applications

Drobotă¹,

Grădinaru²,

Vlad³

et al. 2020

Materials

View full text Add to dashboard Cite

Electrospinning is a widely used technology for obtaining nanofibers from synthetic and natural polymers. In this study, electrospun mats from collagen (C), polyethylene terephthalate (PET) and a blend of the two (C-PET) were prepared and stabilized through a cross-linking process. The aim of this research was to prepare and characterize the nanofiber structure by Fourier-transform infrared with attenuated total reflectance spectroscopy (FTIR-ATR) in close correlation with dynamic vapor sorption (DVS). The studies indicated that C-PET nanofibrous mats shows improved mechanical properties compared to collagen samples. A correlation between morphological, structural and cytotoxic proprieties of the studied samples were emphasized and the results suggest that the prepared nanofiber mats could be a promising candidate for tissue-engineering applications, especially dermal applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Electrospun Collagen Based Composites for Biomedical Applications

Drobotă¹,

Grădinaru²,

Vlad³

et al. 2020

Materials

View full text Add to dashboard Cite

show abstract

“…Electrospinning is a technique mostly preferred in biomedical applications, especially in tissue engineering because of secure processing, tailorability, larger surface area, and constant fiber diameter. ,,,− In this method, a high voltage is applied to the polymer solution, which leads to the development of high electrostatic force at the tip of the needle, and in front of the needle is a grounded collecting electrode. The establishment of a potential difference generates the electrostatic force that is responsible for the spinning of fiber through the Taylor cone.…”

Section: Silk-based Composite Scaffolds and Fabrication Methodsmentioning

confidence: 99%

Silk-Based Composite Scaffolds for Tissue Engineering Applications

Tandon

Kandasubramanian

Ibrahim

2020

Ind. Eng. Chem. Res.

Self Cite

View full text Add to dashboard Cite

Tissue engineering is an interdisciplinary field that aims toward the repair of the tissues and organs by bringing together the chemists, material scientists, and biologists to work in coordination for a better understanding of cell−polymer interactions. The leading challenge in the field of tissue engineering is to mimic the naturally occurring extracellular matrix due to which scaffold engineering has become the central area of research in this field. Various materials have been investigated for the fabrication of scaffolds; silk-based composites are among the most promising materials because of their secure processing, adequate mechanical strength, biodegradability, biocompatibility, hemocompatibility, and oxygen and water permeability. This review extensively focuses on the silk-based composite scaffolds, their fabrication, sterilization, and applications in tissue engineering.

show abstract

“…This can be engineered to resemble the ECM, thus deliver similar mechanical cues that aid regeneration of a wide range of tissues 37 . To significantly impact ES, the mats need to be conductive to some degree.…”

Section: Multiple Es Experiments Have Been Carried Out In Vitromentioning

confidence: 99%

Finite Element Modelling of a Cellular Electric Microenvironment

Verdes

Disney

Phamornnak

et al. 2021

JoVE

View full text Add to dashboard Cite

Clinical studies show electrical stimulation (ES) to be a potential therapy for the healing and regeneration of various tissues. Understanding the mechanisms of cell response when exposed to electrical fields can therefore guide the optimization of clinical applications. In vitro experiments aim to help uncover those, offering the advantage of wider input and output ranges that can be ethically and effectively assessed. However, the advancements in in vitro experiments are difficult to reproduce directly in clinical settings. Mainly, that is because the ES devices used in vitro differ significantly from the ones suitable for patient use, and the path from the electrodes to the targeted cells is different. Translating the in vitro results into in vivo procedures is therefore not straightforward. We emphasize that the cellular microenvironment's structure and physical properties play a determining role in the actual experimental testing conditions and suggest that measures of charge distribution can be used to bridge the gap between in vitro and in vivo. Considering this, we show how in silico finite element modelling (FEM) can be used to describe the cellular microenvironment and the changes generated by electric field (EF) exposure. We highlight how the EF couples with geometric structure to determine charge distribution. We then show the impact of time dependent inputs on charge movement. Finally, we demonstrate the relevance of our new in silico model methodology using two case studies: (i) in vitro fibrous Poly(3,4ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT-PSS) scaffolds and (ii) in vivo collagen in extracellular matrix (ECM).

show abstract

Development of highly porous, Electrostatic force assisted nanofiber fabrication for biological applications

Cited by 26 publications

References 369 publications

Preparation and Characterization of Electrospun Collagen Based Composites for Biomedical Applications

Preparation and Characterization of Electrospun Collagen Based Composites for Biomedical Applications

Silk-Based Composite Scaffolds for Tissue Engineering Applications

Finite Element Modelling of a Cellular Electric Microenvironment

Contact Info

Product

Resources

About