Effect of sex steroids on bone formation in an orthopedically expanded suture in rats

Abstract

Raising the levels of sex steroids in rats revealed positive effects on bone formation in the midpalatal suture in response to expansion. Increased sex steroid levels can reduce the time needed for retention.

Does Shilajit Have an Effect on New Bone Remodelling in the Rapid Maxillary Expansion Treatment? A Biochemical, Histopathological and Immunohistochemical Study

“…Midpalatal suture remodeling plays an active role in the expansion process, but related molecular mechanisms under expansion force are not fully understood. Orthodontists have used different substances during or after RME to increase bone formation and shorten retention period (11).…”

“…Table 4 Effects of Shilajit on IL-1, IL-6, and TNF-α H score analysis at the end of the experimental period. * mean±sd; ** median (min-max); (11).…”

“…Numerous researchers have attempted certain methods to enhance bone remodelling in midpalatal suture, such as bisphosphonates (3), vitamins (4), laser incitement (5)(6)(7)(8), stem cells (9), low-intensity pulsed ultrasound (10), sex steroids (11), hyaluronic acid (12) and antioxidants (13)(14)(15). Right now, antioxidant treatments have been investigated due to their effect on bone metabolism through hindering osteoclastic activity and encouraging osteoblastic activity (14,15).…”

Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study

“…Excessive accumulation of reactive oxygen species (ROS) causes oxidative stress and elicits bone resorption with a direct contribution to bone degradation by osteoclast‐generated superoxide. Additionally, osteoblasts produce antioxidants, including GSH‐Px, to protect against ROS . Antioxidant enzymes such as CAT and GSH‐Px play an important role in scavenging ROS produced under oxidative stress .…”

“…Currently, the effects of various substances have been investigated on new bone formation with the aim of improving the stability of RME . Antioxidant‐related studies are carried out by researchers to investigate the effects of antioxidants on bone metabolism via inhibition of osteoclastic activity and promotion of osteoblastic activity …”