2008
DOI: 10.1007/s10867-008-9105-0
|View full text |Cite
|
Sign up to set email alerts
|

HDF1 and RAD17 Genes are Involved in DNA Double-strand Break Repair in Stationary Phase Saccharomyces cerevisiae

Abstract: DNA repair, checkpoint pathways and protection mechanisms against different types of perturbations are critical factors for the prevention of genomic instability. The aim of the present work was to analyze the roles of RAD17 and HDF1 gene products during the late stationary phase, in haploid and diploid yeast cells upon gamma irradiation. The checkpoint protein, Rad17, is a component of a PCNA-like complex-the Rad17/Mec3/Ddc1 clamp-acting as a damage sensor; this protein is also involved in double-strand break… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
8
0
1

Year Published

2010
2010
2021
2021

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 7 publications
(10 citation statements)
references
References 20 publications
0
8
0
1
Order By: Relevance
“…Of note is rad17 , a component of a PCNA-like complex that is involved in double-strand break repair (Nunes et al, 2008) and has several cis -AREs (Suppl Table 1). Interestingly, Nfe2 seems to be down-regulating genes involved in DNA damage repair, a response that was induced in tBHQ treated zebrafish (Hahn et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Of note is rad17 , a component of a PCNA-like complex that is involved in double-strand break repair (Nunes et al, 2008) and has several cis -AREs (Suppl Table 1). Interestingly, Nfe2 seems to be down-regulating genes involved in DNA damage repair, a response that was induced in tBHQ treated zebrafish (Hahn et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Cisplatin has also additional oxidative effects due to glutathione cross-linking, determining an increase of free radicals induced by ionising radiations. Hence, a complex network with different competitive fluxes and nodal points can determine division delay and DNA repair, or cell death (Lowndes and Murguia 2000, Nyberg et al 2002, Nunes et al 2008, and could explain lethal and mutagenic synergistic interactions observed in case of g þ Pt, g þ E and g þ Pt þ E treatments (Figures 2-5).…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, enzymatic complexes acting either in HR and/or in NHEJ are conserved from yeast to man. It was demonstrated that the balance between HR and NHEJ is different between different cell lines, depending on DNA metabolism, cell population age, cell cycle phase, ploidy and different cell genotypes of a single species (Nunes et al 2008, Shrivastav et al 2008, Huertas 2010. It is considered that HR is the predominant pathway of DSB repair in yeast, whereas in mammalian cells NHEJ is predominant in DSB repair.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations