Identification of Alkaloid Compound and Antioxidant Activity of Rafflesia cantleyi and its Host, Tetrastigma tuberculatum

Zulkffle, Muhammad A.; Osman, Nor S.; Yusoff, Zaini; Kamal, Mohd Lias; Tajam, Jamil

doi:10.2174/2210289201405020018

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…Several species of Rafflesia which has been studied previously also represents a good potential as antioxidant. Zulkffle et al (2014) stated that the Rafflesia cantleyi and host T. tuberculatum absorption of free radical activity is quite high with IC 50 value of 14.58 and 19.12 µg mLG 1 , as well as research and Puttipan and Okonogi (2014) on the Rafflesia kerri, which concludes the high antioxidant potential in the Rafflesia. Hossain et al (2011) stated that the flavonoids and terpenoids are potent antioxidants and the close relationship between the total phenolic content of the extracts with antioxidant activity.…”

Section: Papillosum (Bt1) Extract -----------------------------------mentioning

confidence: 93%

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Phytochemical Screening and Antioxidant Activity of Ethanolic Extract of Rhizanthes deceptor (Rafflesiaceae) and its Host Tetrastigma papillosum

Saleh¹,

Zuhud²,

Sari³

2015

Research J. of Medicinal Plant

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Rhizanthes deceptor is a species that found only in Sumatera, Indonesia. Crude ethanolic extract of Rhizanthes deceptor and it's host, T. papillosum papillosum were examined for their phytochemical properties and antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical qualitative analysis showed that all the extracts, containing alkaloid, phenolic and flavonoid. Triterpenoid detected in bud extract and root extract, saponin detected in root and stem extract and steroid only detected in stem extract. The result showed high level of total phenolic content from all the extract with their value are 431.52, 323.93 and 271.38 mg GAE/g from bud extract of R. deceptor, root and stem of T. papillosum, respectively. Presence of detected secondary metabolites thought to contribute to antioxidant activity of this extract. Antioxidant activity of the plants showed that bud extract of R. deceptor and root and stem extract of T. papillosum had fairly high DPPH antioxidant activity with IC 50 are 32, 22 and 35 µg mLG 1 , respectively. The result of antioxidant activity test indicates that R. deceptor and T. papillosum as, natural sources of antioxidant.

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Section: Papillosum (Bt1) Extract -----------------------------------mentioning

confidence: 93%

“…Research about bioprospecting of Rafflesia has been done in some country. Latest research about Rafflesia kerri carried by Puttipan and Okonogi (2014) while research about Rafflesia cantleyi and its host Tetrastigma tuberculatum carried by Zulkffle et al (2014). Both of this research found high antioxidant ability from their samples.…”

Section: Introductionmentioning

confidence: 90%

Phytochemical Screening and Antioxidant Activity of Ethanolic Extract of Rhizanthes deceptor (Rafflesiaceae) and its Host Tetrastigma papillosum

Saleh¹,

Zuhud²,

Sari³

2015

Research J. of Medicinal Plant

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“…If with Mayer LP, a white or yellow condensed precipitate is formed that dissolves in methanol P. And with Bouchard at LP, a brown to black precipitate is formed. There is a possibility that an alkaloid is present (Zulkffle et al, 2014).…”

Section: Phytochemical Screening Test Alkaloid Identificationmentioning

confidence: 99%

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

Abdillah

Fauziah²,

Lestari³

et al. 2022

Pharmaciana

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Averrhoa bilimbi L. is used widely as spices and traditional medicine, which contained several chemical compounds such as alkaloid, flavonoid, saponin, and tannin. The aim of this study is to discover the best dose of ethyl acetate fraction from A.bilimbi leaves, which have pharmacology activity on total cholesterol and triglycerides in the hypercholesterolemic model. Thirty adult male white mice were divided into six groups; each group was containing five animals. Five groups were given high-fat diet foods and PTU induced the animals to obtain hypercholesterolemia with a frequency of 1 time a day orally for 14 days, while the normal group was given vehicle (Na CMC 5%) and standard feed. On the 15 th day, the normal group was given vehicle (Na CMC 5%), negative control group was given highfat feed, a positive control group was given atorvastatin dose 0.26 mg/kg BW, and another group was given ethyl acetate fraction of A.bilimbi leaves dose 200, 400, and 800 mg/kg BW orally. All animals were treated until the 28 th day. On day 29, the blood were taken to determine the total cholesterol andtriglyceride levels using clinical photometer 5010 v5+. The data were statistically analyzed using a one-way ANOVA followed by the Duncan Multiple Range Test.. This study indicates that administration of ethyl acetate fraction from A.bilimbi leaves can affect the total cholesterol levels and triglycerides in hypercholesterolemic mice (P<0.05). Ethyl acetate fraction dose 200 mg/kg BW shows the best activity in decreasing total cholesterol levels and triglycerides on mice hypercholesterolemic model (P<0.05).

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“…These compounds form about 20% of plant based secondary metabolites and have long history in medication through their diverse pharmacological effects [43]. Zulkffle et al [53,54] identified alkaloid compounds in Tetrastigma tuberculatum using the phytochemical screening method and HPLC technique. It was shown that the radical scavenging activity of T. tuberculatum alkaloids is comparable to the standard reference, BHT but higher than the standard alpha tocopherol.…”

Section: Alkaloidsmentioning

confidence: 99%

The Plant Natural Products: Their Antioxidants, Free Radical Scavengers, DNA Protection and Antimicrobial Activities

Abdel-lateif¹,

Maghrabi²,

Eldeab³

2016

J Bioprocess Biotech

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Identification of Alkaloid Compound and Antioxidant Activity of Rafflesia cantleyi and its Host, Tetrastigma tuberculatum

Cited by 6 publications

References 4 publications

Phytochemical Screening and Antioxidant Activity of Ethanolic Extract of Rhizanthes deceptor (Rafflesiaceae) and its Host Tetrastigma papillosum

Phytochemical Screening and Antioxidant Activity of Ethanolic Extract of Rhizanthes deceptor (Rafflesiaceae) and its Host Tetrastigma papillosum

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

The Plant Natural Products: Their Antioxidants, Free Radical Scavengers, DNA Protection and Antimicrobial Activities

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