Neuro-Immune Relationships At Patients With Chronic Pyelonephrite And Cholecystite. Communication 2. Correlations Between Parameters Eeg, Hrv And Phagocytosis

Kul’chyns’kyi, Andriy B; Kovbasnyuk, Marta M.; Korolyshyn, Tetyana A.; Kyjenko, Valeriy M; Żukow, Walery; Popovych, Igor L.

doi:10.5281/zenodo.163221

Cited by 10 publications

(2 citation statements)

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“…50,51 So let us limit ourselves to the announcement: Naftussya bioactive water has a modulating effect on the autonomic and central nervous systems, which, in turn, activate phagocytosis, as well as modulate cellular and humoral immunity. 33,[52][53][54][55][56][57][58][59]…”

Section: Discussionmentioning

confidence: 99%

“…31,32 Parameters of phagocytic function of neutrophils estimated as described by Kovbasnyuk. 33 The objects of phagocytosis served daily cultures of Staphylococcus aureus (ATCC N 25423 F49) as typical specimen for Gram-positive Bacteria and Escherichia coli (O55 K59) as typical representative of Gram-negative Bacteria. Take into account the following parameters of Phagocytosis: activity (percentage of neutrophils, in which found microbes -Hamburger's Phagocytic Index, PhI), intensity (number of microbes absorbed one phagocytes -Microbial Count MC or Right's Index) and completeness (percentage of dead microbes -Killing Index, KI).…”

Section: Study Design and Proceduresmentioning

confidence: 99%

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The interaction of synbiotic of the environment and the endoecosystem as one of the mechanisms of action of balneotherapy

Popovych¹,

Zukow²,

Fil³

et al. 2023

Eur J Clin Exp Med

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Introduction and aim. Drinking mineral waters are one of the environmental factors that affect the condition of the human body. Of particular interest are therapeutic waters of the Naftussya type, which contain autochthonous microbes and organic oil-like substances and can be considered as a kind of ecosystem. On the other hand, gastrointestinal tract also is an ecosystem that associates a resident microbiota and cells of various phenotypes lining the epithelial wall. We assumed that one of the mechanisms of the therapeutic effect of Naftussya water is the interaction of external and internal ecosystems. This article is the first in a series in support of the hypothesis. Material and methods. The object of clinical-physiological observation were residents of the city of Truskavets’ (21 men aged 24-67 years and 8 women 33-76 years) with chronic pyelonephritis in remission. The objects of study: leukocyturia, bacteriuria, components of microbiota, phagocytosis function of neutrophils, leukocytary adaptation index, plasma and urine electrolytes and nitrogenous metabolites. Results. The weekly use of bioactive Naftussya water from the Opaka deposit causes a favorable normalizing effect on the stool microbiota: it increases the reduced content of Bifidobacteria and Lactobacilli, instead it reduces the increased content of pathogenic strains of Escherichia coli, as well as Klebsiela and Proteus. Reduction of dysbacteriosis is accompanied by an increase in the reduced bactericidal capacity of blood neutrophils against E. coli and Staphylococcus aureus, and reduction of bacteriuria and leukocyturia. At the same time, the elevated level of creatinine in the plasma decreases, instead, the decreased levels of sodium and chloride increase. As expected, the daily diuresis and excretion of urea, creatinine, phosphates, calcium, magnesium and chloride increases, but not sodium and uric acid, the concentrations of which in the urine decrease. The described physiologically beneficial effects are interpreted as adaptogenic, which is confirmed by an increase in the reduced leukocyte adaptation index. Conclusion. The healing effect of Naftussya bioactive water is the result of the interaction of external and internal ecosystems. The next article will consider the role of the nervous and endocrine systems in this interaction.

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Section: Discussionmentioning

confidence: 99%

Section: Study Design and Proceduresmentioning

confidence: 99%

The interaction of synbiotic of the environment and the endoecosystem as one of the mechanisms of action of balneotherapy

Popovych¹,

Zukow²,

Fil³

et al. 2023

Eur J Clin Exp Med

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Cluster analysis of uric acid exchange parameters in female rats

Гоженко

Smagliy

Korda

et al. 2019

J Educ Health Sport

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Background. Uric acid is traditionally considered as the final product of human and primate DNA/RNA degradation, devoid of useful physiological activity. However, there is an opinion that the uric acid molecule, by analogy with methylxanthines (caffeine, theophylin, theobromine) has physiological activity. The acquired experience allows us to offer a topic for future research: "Neurotropic and immunotropic activity of endogenous uric acid". Working hypothesis. Uric acid, interacting with A1 and A2a adenosine receptors as well as phosphodiesterase and Na,K-ATPase of neurons, modulates the activity of nerve centers, which in turn modulate immunocytes. Perhaps the direct effect of uric acid on immunocytes, since the existence of theophylline-resistant and theophylline-sensitive subpopulations of Tlymphocytes has long been known. The proposed article is the first swallow of the announced project. Material and Methods. Experiment was performed on 58 healthy female Wistar rats 220-300 g. Among them 10 animals remained intact, using tap water from drinking ad libitum.The rats of others groups for 6 days administered through the tube various fluids at a dose of 1,5 mL/100 g of body mass. The day after the completion of the drinking course the plasma

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Features of immune status in different states of uric acid metabolism in female rats

Гоженко

Smagliy

Korda

et al. 2019

J Educ Health Sport

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zukow@umk.pl 4 OO Bohomolets' Institute of Physiology, Kyїv i.popovych@biph.kiev.ua AbstractBackground. Previously, we found a wide range of uric acid metabolism parameters and functional relationships of uricemia and uricosuria with the parameters of immunity in healthy female rats analyzed. It was found by canonical correlation analysis that both parameters of uric acid metabolism determine the immunity status of rats by 71%. The purpose of this study is to determine the features of immune status in rats with quantitatively and qualitatively different uric acid metabolism. Material and Methods. Experiment was performed on 60 healthy female Wistar rats 220-300 g. Among them 10 animals remained intact, using tap water from drinking ad libitum. The rats of others groups for 6 days administered through the tube various fluids. The serum and urine levels of the uric acid (uricase method) were determined. In the blood, the parameters of immunity were determined. From thymus and spleen made smears-imprints for counting splenocytogram and thymocytogram. For them, as well as immunocytogram and leukocytogram of blood, Shannon's entropy was calculated. Results. Screening of immune profiles of four quantitative and qualitative uric acid metabolism clusters revealed 6 functionalmetabolic patterns, two of which are quasilinear (enhancing and suppressing), with immune extremes at moderately elevated uricemia, two U-shaped with immune optimum at moderately reduced uricemia levels, as well as a non-reactive pattern. Discriminant analysis revealed 14 parameters of immunity, the constellation of which four clusters of metabolism of uric acid clearly distinguish. Conclusion. Endogenous uric acid exerts a modulatory immunotropic effect in healthy female rats.168

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Neuro-Immune Relationships At Patients With Chronic Pyelonephrite And Cholecystite. Communication 2. Correlations Between Parameters Eeg, Hrv And Phagocytosis

Cited by 10 publications

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The interaction of synbiotic of the environment and the endoecosystem as one of the mechanisms of action of balneotherapy

The interaction of synbiotic of the environment and the endoecosystem as one of the mechanisms of action of balneotherapy

Cluster analysis of uric acid exchange parameters in female rats

Features of immune status in different states of uric acid metabolism in female rats

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