Novel Biodegradable Polymer/Bioactive Glass Composites for Tissue Engineering Applications

Stamboulis, Artemis; Boccaccını, Aldo R.; Hench, Larry L.

doi:10.1002/1527-2648(200203)4:3<105::aid-adem105>3.0.co;2-l

Cited by 82 publications

(52 citation statements)

References 16 publications

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“…The materials are intended as scaffolds for bone tissue engineering applications. This study extends related recent research on composite materials based on bioresorbable Bio-glasss-coated surgical sutures [20,21] and meshes [22].…”

Section: Introductionsupporting

confidence: 84%

“…The composite materials were made using a slurry-dipping technique, similar to that proposed by Boccac-cini et al, to coat surgical sutures and polymeric meshes with Bioglass® particles [21,22]. The technique involved the preparation of a stable slurry with 42wt% of Bioglass® particles in distilled and deionised water.…”

Section: Methodsmentioning

confidence: 99%

“…In some cases, degradation products were formed, including numerous stable and highly crystalline particles, which were responsible for a delayed inflammation and foreign body reactions at the site of implantation [36]. In the case of polymer/Bioglass® composites, the bioactive glass coating should act as a protective hydrolysis barrier affecting both the extent and rate of degradation of the polymer substrate, as found in recent investigations [20][21][22]. The rapid exchange of protons in water for alkali in the glass provide a pH buffering effect at the polymer surface, therefore acceleration of degradation will not occur due to small pH changes during bioactive glass dissolution.…”

Section: In Vitro Studies In Sbfmentioning

confidence: 99%

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Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

et al. 2002

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Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering.

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Section: Introductionsupporting

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Section: In Vitro Studies In Sbfmentioning

confidence: 99%

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Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

et al. 2002

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“…Ti-6Al-4V is 110 GPa, which is around 40 to 2000 times higher than that of natural bone tissue (0.05 − 30 GPa) (18,34). This high modulus would result in a stress-shielding effect at the bone-implant interface, leading to bone resorption and fibrous tissue encapsulation (35).…”

Section: Discussionmentioning

confidence: 99%

Porous Titanium‐6 Aluminum‐4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly‐Ether‐Ether‐Ketone Cage in Sheep Vertebral Fusion

et al. 2013

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Abstract:Interbody fusion cages made of poly-ether-etherketone (PEEK) have been widely used in clinics for spinal disorders treatment; however, they do not integrate well with surrounding bone tissue. Ti-6Al-4V (Ti) has demonstrated greater osteoconductivity than PEEK, but the traditional Ti cage is generally limited by its much greater elastic modulus (110 GPa) than natural bone (0.05-30 GPa).In this study, we developed a porous Ti cage using electron beam melting (EBM) technique to reduce its elastic modulus and compared its spinal fusion efficacy with a PEEK cage in a preclinical sheep anterior cervical fusion model. A porous Ti cage possesses a fully interconnected porous structure (porosity: 68 ± 5.3%; pore size: 710 ± 42 μm) and a similar Young's modulus as natural bone (2.5 ± 0.2 GPa). When implanted in vivo, the porous Ti cage promoted fast bone ingrowth, achieving similar bone volume fraction at 6 months as the PEEK cage without autograft transplantation. Moreover, it promoted better osteointegration with higher degree (2-10x) of bone-material binding, demonstrated by histomorphometrical analysis, and significantly higher mechanical stability (P < 0.01), shown by biomechanical testing. The porous Ti cage fabricated by EBM could achieve fast bone ingrowth. In addition, it had better osseointegration and superior mechanical stability than the conventional PEEK cage, demonstrating great potential for clinical application.

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“…A majority of these techniques utilize three-dimensional scaffold structures composed of natural or synthetic polymers [3][4][5][6][7][8][9][10]. These scaffold structures are typically endowed with complex internal architecture, channels and porosity that provide sites for cell attachment and proliferation, as well as for conveying cells, growth factors and biomolecular signals to promote tissue regeneration at an implantation site.…”

Section: Introductionmentioning

confidence: 99%

Computational Design, Freeform Fabrication and Testing of Nylon-6 Tissue Engineering Scaffolds

et al. 2002

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Advanced and novel fabrication methods are needed to build complex three-dimensional scaffolds that incorporate multiple functionally graded biomaterials with a porous internal architecture that will enable the simultaneous growth of multiple tissues, tissue interfaces and blood vessels. The aim of this research is to develop, demonstrate and characterize techniques for fabricating such scaffolds by combining solid freeform fabrication and computational design methods. When fully developed, such techniques are expected to enable the fabrication of tissue engineering scaffolds endowed with functionally graded material composition and porosity exhibiting sharp or smooth gradients. As a first step towards realizing this goal, scaffolds with periodic cellular and biomimetic architectures were designed and fabricated using selective laser sintering in Nylon-6, a biocompatible polymer. Results of bio-compatibility and in vivo implantation studies conducted on these scaffolds are reported.

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Novel Biodegradable Polymer/Bioactive Glass Composites for Tissue Engineering Applications

Cited by 82 publications

References 16 publications

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

Porous Titanium‐6 Aluminum‐4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly‐Ether‐Ether‐Ketone Cage in Sheep Vertebral Fusion

Computational Design, Freeform Fabrication and Testing of Nylon-6 Tissue Engineering Scaffolds

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