Pharmacodynamics of a losartan transdermal system for the treatment of hypertension

Shams, Mohammad S.; Alam, Mohammad; Ali, Asgar; Sultana, Yasmin; Aqil, Mohd.

doi:10.3109/03639040903188471

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…The optimized formulation were evaluated for clarity, pH measurement, drug content, gelation temperature, spreadability, CPR at 6 h, CPR at 2 h, and t 50% . [30]…”

Section: Methodsmentioning

confidence: 99%

Formulation and evaluation of periodontal in situ gel

Garala

Joshi

Shah

et al. 2013

Int J Pharma Investig

142

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Background:The present study was aimed to develop and optimize in situ gel for the treatment of periodontal disease.Materials and Methods:Temperature-sensitive in situ gel containing 0.1% w/v Chlorhexidine hydrochloride was formulated by cold method using different polymers. Preliminary study was carried out to optimize different types and concentration of polymers such as Poloxamer 188, Poloxamer 407, Gellan gum, and Carbopol 934P. Central composite design was employed for optimization of the effect of independent variables such as Poloxamer 407 and Carbopol 934P on responses such as gelation temperature, spreadability, cumulative percentage release at 2 h, and time for 50% drug release (t50 %). Each formulations were evaluated for clarity, pH, gelation temperature, spreadability, drug content, in vitro drug release, t50 %, and cumulative percentage drug release at 2 h.Results:Results of evaluation parameters revealed that the drug release, gelation temperature was considerably decreased with increasing t50 % as the concentration of each polymer was increased. The desirability function was utilized to find out optimized formulation of the factorial design. Formulation F6 showed the highest overall desirability of 0.6283 and, therefore, this formulation was considered to be the optimized formulation. The % relative error was calculated, which showed that observed responses were in close agreement with the predicted values calculated from the generated regression equations.Conclusion:The clarity, pH, drug content of all formulations was found to be satisfactory. Further, all the formulations showed sustained drug release for a period of 6 h, which satisfied to treat periodontal disease.

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“…The optimized formulation were evaluated for clarity, pH measurement, drug content, gelation temperature, spreadability, CPR at 6 h, CPR at 2 h, and t 50% . [30]…”

Section: Methodsmentioning

confidence: 99%

Formulation and evaluation of periodontal in situ gel

Garala

Joshi

Shah

et al. 2013

Int J Pharma Investig

142

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“…The uniform weight formula showed that the formulation of the patch had the same material composition or did not differ much. This indicated the uniformity of the active substance content in the formula [18].…”

Section: Weight Uniformitymentioning

confidence: 75%

Formulation and Effectiveness Test of Analgesic Patch from Itchy Leaves (Laportea decumana (Roxb.) Wedd)

Tolip¹,

Simaremare²,

Pratiwi³

2021

Curr. Appl. Sci. Technol.

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The leaves of the Itchy leaves plant (Laportea decumana (Roxb.) Wedd) are considered very effective in Papuan traditional medicine as a natural anti-pain (analgesic) treatment. This study aimed to determine the quality and effectiveness of the analgesic patches made from the Itchy leaves plant. Three formulas were used with the composition of the simplicia in the formula; FI 0.38% (w/v), FII 1.11% (w/v), and FIII 1.80% (w/v). The patch quality evaluation included organoleptic qualities, weight variation, folding endurance, thickness, drying loss, percent elongation, and an irritation test. In the analgesic effect test, the wriggling method was used on mice, and induced intraperitoneally with acetic acid. The mice were divided into five groups: negative control, positive control, and three groups receiving doses using patches FI, FII, and FIII. The observation of wriggling was calculated in 5-min intervals for 1 h. Data were analyzed statistically using the one-way ANOVA test and the least significant difference (LSD) test with a significant level of 5% (p≤0.05). The results showed that patches had an imperfect round shape, distinctive odor, green color, consistent weight, consistent thickness, flexibility, elasticity, and produced a little irritation, which was not harmful. The results of the statistical analysis of FI, FII, and FIII of the Itchy leaf patch (Laportea decumana (Roxb.) Wedd) showed significant differences in analgesic effects. The analgesic effect test results showed that patch FII with a crude drug composition of 1.11% (w/w) had the best reduction in wriggling responses in mice, with a protective power of 68.69%.

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“…The optimized formulations were evaluated for clarity, pH measurement, drug content, gelation temperature. 48 …”

Section: Stability Studymentioning

confidence: 97%

Formulation, Characterization and Evaluation of a Thermoresponsive <I>In</I> <I>Situ</I> Gel Containing Gallic Acid-Loaded Chitosan Nanoparticles for the Treatment of Periodontal Disease

Patil¹,

Jobanputra²

2015

j bionanosci

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The present work describes the formulation, characterization and preliminary in vitro drug release studies of a thermoresponsive in situ gel containing gallic acid-loaded chitosan nanoparticles (CGNPs). Chitosan nanoparticles were achieved using the ionic gelation method and the in situ gel was prepared via a cold method. Developed CGNPs were characterized for particle size and zeta potential. Pluronic F127 was used as a gelling agent for dental therapy. Formulated in situ gel was evaluated for clarity, pH, gelation temperature, viscosity, spreadability, drug content, texture profile and stability. The antibacterial potential of CGNPs-gel was evaluated against isolated dental pathogens, in vitro. Results revealed that in situ gel exhibited promising antibacterial activity against dental pathogens viz. Acinetobacter junii and Bacillus species. The results of the in vitro release study indicated that in situ gel achieved superior sustained-release of gallic acid (84% up to 6 hours), so that the formulation could significantly increase gallic acid bioavailability in the periodontal cavity.In conclusion, the in situ gel formulation developed in this work has significant potential for dental applications.

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Pharmacodynamics of a losartan transdermal system for the treatment of hypertension

Abstract: It can be concluded that the developed transdermal matrix patch holds promise for the management of hypertension that needs to be validated by clinical trials.

Cited by 12 publications

References 8 publications

Formulation and evaluation of periodontal in situ gel

Formulation and evaluation of periodontal in situ gel

Formulation and Effectiveness Test of Analgesic Patch from Itchy Leaves (Laportea decumana (Roxb.) Wedd)

Formulation, Characterization and Evaluation of a Thermoresponsive <I>In</I> <I>Situ</I> Gel Containing Gallic Acid-Loaded Chitosan Nanoparticles for the Treatment of Periodontal Disease

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