Simultaneous determination of paracetamol, caffeine and acetylsalicylic acid by means of a FI ultraviolet pls multioptosensing device

Ruiz-Medina, A.; Córdova, M.L. Fernández de; Molina‐Díaz, Antonio

doi:10.1016/s0731-7085(99)00216-2

Cited by 51 publications

(24 citation statements)

References 15 publications

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“…(21) is so low that small changes in the reaction conditions, after several months, might result in significant changes in the slope. When results for the lowest ASA concentration are not considered, both absolute and relative errors are comparable with those found with new methods proposed for the resolution of mixtures of ASA and AAP [26,27,28,29]. On the other hand, the analytical signal is not an absolute value of the experimental measurement (absorbance), but is generated by a change of it (∆A or the slope).…”

Section: Simultaneous Determination Of Asa and Hqsupporting

confidence: 68%

The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

López-Cueto

Ostra

Ubide

2002

Analytical and Bioanalytical Chemistry

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When acetylsalicylic acid (ASA) is added to a bromine solution, slow decay of the bromine concentration occurs. Hydrolysis of ASA yields salicylic acid (SA) slowly, and bromine reacts rapidly with SA but not with ASA. Simulated reaction profiles based on a two-step reaction scheme agree closely with the experimental profiles. This behaviour can be used to develop kinetic methods for resolution of mixtures of ASA and a second component that reacts rapidly with bromine. A remarkable practical feature of these methods is that the faster the reaction between bromine and the second component, the simpler and easier the analytical method. The reaction between hydroquinone (HQ) and bromine is rapid and a very simple analytical method is proposed. Mean validation errors of 2.8% for HQ and 7.2% for ASA have been found with concentration ratios [ASA]:[HQ] ranging between 0.32 and 19.4. The reaction between paracetamol (AAP) and bromine is not so fast and more complicated calibration methods are required. After use of a calibration plane mean validation errors of 2.7% for AAP and 8.1% for ASA have been found with concentration ratios ranging between 1.28 and 77.5. Similar kinetic approaches should be possible with many other mixtures of ASA and a second fast-reacting component, because bromine reacts with many inorganic and organic species by oxidation-reduction, substitution, and addition reactions.

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Section: Simultaneous Determination Of Asa and Hqsupporting

confidence: 68%

The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

López-Cueto

Ostra

Ubide

2002

Analytical and Bioanalytical Chemistry

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“…For the assay of acetylsalicylic acid, paracetamol, and caffeine in such mixtures, different methods have been reported, including spectrophotometry [8], derivative spectrophotometry [9], flow injection partial least-squares UV spectrophotometry [10,11], stopped-flow Fouriertransform infra-red spectrometry [12], planar chromatography [13,14], solid phase spectroscopy [15], and micellar electrokinetic chromatography [16].…”

Section: Sequential Injection Chromatography (Sic) Is a New Area Of Amentioning

confidence: 99%

Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets

Šatı́nský

Neto

Solich

et al. 2004

J of Separation Science

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In this contribution, a new separation method for simultaneous determination of paracetamol, caffeine, acetylsalicylic acid, and internal standard benzoic acid was developed based on a novel reversed-phase sequential injection chromatography (SIC) technique with UV detection. A Chromolith Flash RP-18e, 25-4.6mm column (Merck, Germany) and a FIAlab 3000 system (USA) with an 8-port selection valve and a 5 mL syringe were used for sequential injection chromatographic separations in our study. The mobile phase used was acetonitrile-(0.01 M) phosphate buffer (10:90, v/v) pH 4.05, flow rate 0.6 mL min(-1). UV detection was at 210 and 230 nm. The validation parameters showed good results: linearity (r >0.999) for all compounds, detection limits in the range 0.3-0.8 microg mL(-1), repeatability (RSD) of peak heights between runs in the range 1.10-4.30% at three concentration levels and intra-day repeatability of the retention times in the range 0.28-0.43%. The analysis time was <6 min. The method was found to be applicable for the routine analysis of the active compounds paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets.

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“…Recently, several flow injection (FI) methods for the determination of paracetamol have been proposed using an UV-Vis spectrophotometer [20][21][22], fluorimeter [23], multioptosensor [24], or Fourier transform infrared spectrophotometer [25] as a detector.…”

Section: Introductionmentioning

confidence: 99%

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

Razmi

Harasi

2008

JICS

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The present work describes a rapid and accurate amperometric technique for the determination of acetaminophen (ACT) in pharmaceutical preparations and human blood serum, based on electrocatalytic oxidation of ACT at a glassy carbon electrode modified by cadmium pentacyanonitrosylferrate (CdPCNF) film. The electrocatalytic response of the modified GC electrode was linear over the concentration of 1.64-52.90 μM. The limit of detection was found to be 2.04 μM by amperometric technique. The method was successfully utilized for the determination of ACT in various pharmaceutical preparations and the results have been statistically compared with those obtained by the official method. The interference of some pharmaceutical and biological compounds was investigated. The results of interference study showed that the Nafion-coated CdPCNF|GC electrode can be utilized as a selective amperometric sensor for acetaminophen determination in human blood serum. The mean value of rate constant k for catalytic reaction, and the diffusion coefficient of ACT (D) in the phosphate buffer solution of pH 7.2 were found to be 4.27 10 2 M -1 s -1 , and (4.25 ± 0.33) 10 -6 cm 2 s -1 , respectively.

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Simultaneous determination of paracetamol, caffeine and acetylsalicylic acid by means of a FI ultraviolet pls multioptosensing device

Cited by 51 publications

References 15 publications

The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

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