The determination of antioxidants activity and sunblock Sterculia populifolia extract- based cream

Khairi, Nur; As’ad, Suryani; Djawat, Khaeruddin; Alam, Gemini

doi:10.18502/pbr.v4i1.142

Cited by 7 publications

(7 citation statements)

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“…Plants have evolved self-protection mechanisms to avoid damage because, in plants, exposure to sunlight is required for photosynthesis. Bioactive compounds such as phenol have antioxidant properties in plants [7,8]. As a result, phytochemical analysis of plants has become an increasingly important method in plant medicine and drug research [9].…”

Section: Introductionmentioning

confidence: 99%

Gas Chromatography Study of N-Hexane and Chloroform Fractions of Ethanol Extract of Melastoma Malabathricum L. Leaves: An in Vitro Study of Antioxidant and SPF Values

Apridamayanti

Pratiwi

Sari

2022

Int J Pharm Pharm Sci

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Objective: This research aimed to qualitatively determine the chemical compound constituents, antioxidant capacity, and sun protection factor (SPF) value of extract of the leaves of Melastoma malabathricum L. using GC-MS. Methods: The detected compounds were identified by processing the raw GC-MS data using ChemStation software and comparing results with the NIST mass spectral database. Antioxidant capacity was measured using 1,2-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging and ferric-reducing antioxidant power (FRAP) assays. The SPF contained in the n-hexane and chloroform fractions separated from the ethanol extract of the leaves of Melastoma malabathricum L was identified. Results: The GC-MS test results revealed that 21 and 29 peaks of separation occurred in the n-hexane and chloroform fractions. The highest peak values are hexadecanoic acid methyl ester (a fatty acid group also known as palmitic acid) (100%) in the n-hexane and chloroform fractions. The highest chemical content in n-hexane and chloroform fractions was obtained at 20 min. The thin-layer chromatography (TLC) results indicated that the n-hexane and chloroform fractions contained steroid and terpenoid compounds. The antioxidant capacity test using DPPH showed that the n-hexane and chloroform fractions of ethanol extract of the leaves of Melastoma malabathricum L had IC50 values of 49.2±7.9 g/ml and 11.3±3.65 g/ml, respectively. Using FRAP, the IC50 values of the n-hexane and chloroform fractions were identified as 365.2±133.6 g/ml and 80.8±8.9 g/ml, respectively, categorizing them as strong and weak antioxidants. SPF testing produced SPF values for the n-hexane and chloroform fractions of ethanol extract of Melastoma malabathricum L leaves of 11.7±0.1 and 21±0.4, respectively. Conclusion: The study results show that the antioxidant activity and the SPF values of the chloroform fraction are greater than those of the n-hexane fraction. In conclusion, the n-hexane and chloroform fractions are found to have antioxidant properties in the weak and solid categories and the ability to protect against sunlight in the vulnerable category.

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Section: Introductionmentioning

confidence: 99%

Gas Chromatography Study of N-Hexane and Chloroform Fractions of Ethanol Extract of Melastoma Malabathricum L. Leaves: An in Vitro Study of Antioxidant and SPF Values

Apridamayanti

Pratiwi

Sari

2022

Int J Pharm Pharm Sci

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“…It means that 100 µL of our cream formulation diluted 5 times in water can neutralize 0.152 µmol of radical in half an hour. Similar research was done with a formulation containing Sterculia populifolia extract as an antioxidant [ 32 ]. Its authors showed that a concentration of 100 µg/mL of this extract can neutralize 50% of radicals in 3 mL of 0.004% (w/w) solution of DPPH, which gives 0.152 µmol.…”

Section: Resultsmentioning

confidence: 91%

Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure

Lewińska

Domżał-Kędzia

Kierul³

et al. 2021

Molecules

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The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, respectively. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, additionally consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions.

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“…According to Khairi et al, Klika Faloak extract indicated as a powerful antioxidant with score for IC 50 16.56 ppm. This powerful antioxidant was caused by the flavonoid and polyphenol compound which contain inside the Klika Faloak [20]. Flavonoids and polyphenols in Klika Faloak extract could prevent damage caused by free radicals in several ways, one of which is destroying free radicals directly [21].…”

Section: Discussionmentioning

confidence: 99%

Effects of Klika Faloak (

Khairi

As’ad

Djawad

et al. 2019

Egyptian Journal of Basic and Clinical Pharmacology

Self Cite

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Klika Faloak (Sterculia Populifolia) extract contains flavonoid and polyphenol compounds which are the most potential components in reducing ROS (Radical Oxidative Superoxide) to prevent free radical caused by UV-B radiation. This study aimed to prove that Klika Faloak extract cream could reduce the expression of matrix metalloproteinase-1 (MMP-1) in albino mice exposed to UV-B radiation. This study was a laboratory experimental study using randomized pre and post-test design. Albino mice were divided into 3 groups; group 1 was treated with 0.1 mg/cm 2 on 3 cm 2 of radiation area with 5% Klika Faloak extract cream for four weeks and exposed to UVB radiation, group 2 was treated with 0.1 mg/cm 2 on 3 cm 2 of radiation area with base cream/ placebo for four weeks and exposed to UVB radiation, and group 3 was controlled group which not given anything and not exposed to UVB radiation. Prior to the treatment, MMP-1 expression was examined through blood serum and then the treatment group was exposed to UV-B radiation at a dose of 500 mJ/cm 2 for 4 weeks. After that skin biopsy was performed to examine MMP-1 expression. Data were analyzed using one way ANOVA to determine significant difference among three groups then followed by a post hoc test using the LSD (Least Significance Difference) to determine the smallest significant level <0.05. The result showed average decreasing of MMP-1 expression in group 1 compared to group 2 and group 3. It could be concluded that Klika Faloak extract cream could reduce MMP-1 expression.

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The determination of antioxidants activity and sunblock Sterculia populifolia extract- based cream

Cited by 7 publications

References 0 publications

Gas Chromatography Study of N-Hexane and Chloroform Fractions of Ethanol Extract of Melastoma Malabathricum L. Leaves: An in Vitro Study of Antioxidant and SPF Values

Gas Chromatography Study of N-Hexane and Chloroform Fractions of Ethanol Extract of Melastoma Malabathricum L. Leaves: An in Vitro Study of Antioxidant and SPF Values

Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure

Effects of Klika Faloak (

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