The Effect of Solvent Hydrophilicity on the Enzymatic Ring-Opening Polymerization of L-Lactide by Candida rugosa Lipase

Curie, Catia Angli; Darmawan, Muhammad Arif; Dianursanti, Dianursanti; Budhijanto, Wiratni; Gozan, Misri

doi:10.3390/polym14183856

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…A high Log P value indicates that a molecule is more non-polar and has a high ability to penetrate the lipid bilayer [23]. However, a high Log P value indicated that the molecule is difficult to dissolve in water because it is more non-polar or hydrophobic [25]. The hydrophobic nature is related to the ability of the drug to penetrate the lipid bilayer.…”

Section: Resultsmentioning

confidence: 99%

In Silico Assay of Antibacterial Activity of Binahong (Anredera cordifolia) Leaf Extract to Streptococcus pneumoniae

2023

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Pneumonia is a disease that frequently infects toddlers. Pneumonia cases in 2021 caused 9.4% of deaths in children aged 12-59 months. The effectiveness of pneumonia treatment is decreasing due to the increase of Streptococcus pneumoniae’s resistance to antibiotics. The application of natural plant extracts such as binahong (Anredera cordifolia) leaf extract is chosen as an alternative treatment to pneumonia. The purpose of this study was to disclose the active compound of binahong leaf extract (A. cordifolia) that has the potential as an antibacterial to S. pneumoniae. This study was conducted in September 2022 at Universitas Negeri Surabaya with in silico method (blind docking) using PyRx software. The results of the drug-likeness assay showed that the three selected compounds (Linoleic Acid, Phytol, and Hexadecanoid Acid) met the criteria as drugs. The molecular docking assay that has been carried out showed that Linoleic Acid has the lowest binding affinity value (-5.4 kcal/mol) when compared to Phytol and Hexadecanoid Acid indicating its higher potential. This study shows that the selected compounds of the binahong leaf extract have the potential to be antibacterial to S. pneumoniae with PBP2 as the target protein. It is nevertheless necessary to conduct further research to determine the effectiveness and bioavailability of these compounds.

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Section: Resultsmentioning

confidence: 99%

In Silico Assay of Antibacterial Activity of Binahong (Anredera cordifolia) Leaf Extract to Streptococcus pneumoniae

2023

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“…A copolymer with an Mn of 3100 g/mol was obtained after 14 days at a reaction temperature of 80 °C. Curie et al [ 179 ] measured the effects of six organic solvents and ILs (1-butyl-3-methyl-imidazolium hexafluorophosphate, [BMIM][PF6]) on eROP. The results have shown that the highest molecular weight and conversion were obtained in the ionic liquid [BMIM][PF6], which were 3108 g/mol of Mn and 93.2%, respectively.…”

Section: Solvent System For Enzyme-catalyzed Synthesis Of Polyestersmentioning

confidence: 99%

Recent Advances in the Enzymatic Synthesis of Polyester

Wang

Liu²,

Lee

et al. 2022

Polymers

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Polyester is a kind of polymer composed of ester bond-linked polybasic acids and polyol. This type of polymer has a wide range of applications in various industries, such as automotive, furniture, coatings, packaging, and biomedical. The traditional process of synthesizing polyester mainly uses metal catalyst polymerization under high-temperature. This condition may have problems with metal residue and undesired side reactions. As an alternative, enzyme-catalyzed polymerization is evolving rapidly due to the metal-free residue, satisfactory biocompatibility, and mild reaction conditions. This article presented the reaction modes of enzyme-catalyzed ring-opening polymerization and enzyme-catalyzed polycondensation and their combinations, respectively. In addition, the article also summarized how lipase-catalyzed the polymerization of polyester, which includes (i) the distinctive features of lipase, (ⅱ) the lipase-catalyzed polymerization and its mechanism, and (ⅲ) the lipase stability under organic solvent and high-temperature conditions. In addition, this article also focused on the advantages and disadvantages of enzyme-catalyzed polyester synthesis under different solvent systems, including organic solvent systems, solvent-free systems, and green solvent systems. The challenges of enzyme optimization and process equipment innovation for further industrialization of enzyme-catalyzed polyester synthesis were also discussed in this article.

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Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties

Wang,

Li,

Meng

et al. 2024

Biocatalysis and Biotransformation

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The Effect of Solvent Hydrophilicity on the Enzymatic Ring-Opening Polymerization of L-Lactide by Candida rugosa Lipase

Cited by 3 publications

References 43 publications

In Silico Assay of Antibacterial Activity of Binahong (Anredera cordifolia) Leaf Extract to Streptococcus pneumoniae

In Silico Assay of Antibacterial Activity of Binahong (Anredera cordifolia) Leaf Extract to Streptococcus pneumoniae

Recent Advances in the Enzymatic Synthesis of Polyester

Enzymatic synthesis of tyrosol esters in organic solvents and ionic liquids: Correlation between enzyme activity and solvent properties

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