Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats

Abstract

Background. Gastroesophageal reflux disease (GERDs) is a common chronic digestive system disease, in which the symptoms of reflux esophagitis (RE) seriously affect the quality of life. Aims. We aimed to study the therapeutic effect of Zhujie Hewei granules (ZHG) on reflux esophagitis in model rats. Materials and Methods. A rat model of RE was established with the steps of half pylorus ligation, cardiotomy, and hydrochloric acid perfusion. The rats in treatment groups were orally administered with 1.30, 2.60, or 5.20 g/kg ZHG once daily for 28 days. Histopathological changes of the esophagus were observed with hematoxylin-eosin staining. The content of total bilirubin and pH in gastric juice was determined. Esophageal mucosal injury was assessed by macroscopic observation scores, mucosal injury index scores, and esophageal inflammation scores. The levels of gastrin (GAS), motilin (MTL), and vasoactive intestinal peptide (VIP) in serum were evaluated by using ELISA kits. Results. After treatment with ZHG, the body weight of RE rats tended to increase drastically, the macroscopic observation scores of the esophagus mucous membrane decreased (P<0.05), the mucosal injury index scores decreased (P<0.05), the gastric pH values increased (P<0.05), and the levels of serum MTL and VIP decreased (P<0.05). In addition, the high dose of the ZHG-treated group showed lower serum GAS (P<0.05), while the high and middle doses of the ZHG-treated groups showed lower esophageal inflammation scores (P<0.05). Conclusions. ZHG was effective in treating RE in rats due using mechanisms including improving the pH value of gastric contents, decreasing the gastrointestinal hormones (including GAS, MTL, and VIP), and improving the inflammatory damage.

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats

“…However, these drugs have been reported to have no significant results in 20~30% of patients, and the main pathogenic factors cannot be reduced, making complete treatment difficult. In addition, it is known that serious complications occur when used for a long time [ 32 , 33 ]. Therefore, in the current study, research on traditional Korea medicine that shows benefits in reducing recurrence and side effects and alleviating symptoms has been actively conducted [ 34 – 36 ].…”

Digestion‐Promoting Effects and Mechanisms of Dashanzha Pill Based on Raw and Charred Crataegi Fructus

“…Several studies have shown that gastrointestinal hormones play an important role in the regulation of gastrointestinal function [25–27] . GAS, the first identified gastrointestinal peptide, is essential in certain digestive processes, such as gastric acid secretion and intestinal motility [28,29] .…”

“…Several studies have shown that gastrointestinal hormones play an important role in the regulation of gastrointestinal function. [25][26][27] GAS, the first identified gastrointestinal peptide, is essential in certain digestive processes, such as gastric acid secretion and intestinal motility. [28,29] MTL is involved in food intake regulation, stimulating the contractile movements of the gastric sinus and fundus, and promoting the contraction of the smooth muscle of the gastrointestinal tract.…”

Efficacy and safety of traditional Chinese herbal formula combined with western medicine for gastroesophageal reflux disease

“…[ 14 ] Also, they could improve the pH value of gastric contents, decrease the gastrointestinal hormones, and improve the inflammatory damage in rats. [ 15 ] A combination of Chinese herbal formula and western medicine against GERD could significantly improve the treatment effect and reduce the side effects of western medicine.…”