The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests. The rats were divided into three groups, each having twenty animals. Group 1 served as a control having wound. Other two groups received either NS oil or zinc-silver cream in addition to the wound. The study was initiated after the animals rested for 2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and antioxidant values were determined with respect to biochemical oxidative stress results (P<0.01). Wound sites of 10 animals from each group were allocated for histopathological examinations, and those of the remaining 10 animals from each group were used in biomechanical testing. Histopathological examination revealed that epithelization occurred in all groups. Inflammatory response with an intensive vascularization was present in the samples of the silver group (P<0.01). Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.

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Pain control is a common clinical approach in trauma and postoperative care especially complicated orthopedic surgeries to ease the deleterious effects of pain. Various kinds of pain killers have been used, and nowadays nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs for pain control purposes. Prostaglandin-endoperoxide synthetase, also commonly called cyclooxygenase (COX), is one of the key enzymes in prostaglandin bio-synthesis. The COX enzymes have subgroups of enzymes, each of which suppresses different inflammatory mediators. These enzymes are involved in different functions, some of which are essential for continuity of physiological processes. Thus, NSAIDs are expected not to cause any change of functions of some enzymes while suppressing others. Among the COX enzymes, COX-1 is associated with gastrointestinal system functions and gastrointestinal mucosa while COX-2 is associated with inflammation and pain. Like most drugs, NSAIDs have known and possible side effects. In various studies related to NSAIDs, inhibitory effects of conventional NSAIDs with non-selective effects and specific COX-2 inhibitors on bone healing have been reported. In this study, the effects of ketoprofen and meloxicam on bone fracture healing induced in 24 adult male Wistar rats was studied by Dual Energy X-Ray Absorptiometry (DEXA). The results indicates that meloxicam inhibits the fracture healing to some degree.

No abstract

The aim of this study is to compare the effects of ethacridine lactate and hypochlorous acid on wound healing in rats through clinical and histopathological studies. The rats were divided into three groups; group 1; control group, group 2; hypochlorous acid (HOCL) group, group 3; ethacridine lactate (EL) group. Each group contained seven animals. Under anesthesia, a 20 mm long full layer skin resection was performed from dorsal interscapular region. Wound sizes were measured with millimetric paper on the 3rd, 7th and 14th day postoperatively. At the end of the 14th day, the animals were sacrificed under deep anesthesia and extensive skin resection of the wound area was performed and sent for histopathological examination. Macroscopic examination of wounds revealed that the wound was completely closed without any crust formation in the HOCL group, and also there was only a scar left in some animals of the HOCL group at the end of 14th day. Mild inflammatory cell, intense fibroblast activity and the lowest SOD and GPx immunoreactivity were found in the HOCL group compared to the other two groups (P<0.05). Consequently, it was observed that macroscopically and histopathologically, the wound healing was faster in animals treated with HOCL compared to those who were in the EL and the control group.