The response of giant lymph node hyperplasia (Castleman's disease) to surgery is well known and surgery is the main technique in the management of these patients. We describe a young man who presented with clinical features suggestive of a lymphoma, but who was diagnosed to have Castleman's disease after histopathology. Complete response to radiation and a disease-free follow- up of 22 months prompts us to advocate radiation as an effective alternative mode of therapy in inoperable cases. Giant lymph node hyperplasia or Castleman's disease is a benign condition with enlargement of the lymph nodes, particularly common in the mediastinum. The patients are otherwise usually asymptomatic but may sometimes present with fever, anaemia, hyper-gammaglobulinaemia (Bartoli et al, 1980; Frrizera et al, 1983) and multi-centric lymph node enlargement (Gaba et al, 1978) mimicking a lymphoma.

In a 9-month-old girl a subperiosteal metastasis of the maxillary bone developed in the contralateral orbit about one year after enucleation of a poorly differentiated retinoblastoma.

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Non-secretory parathyroid adenomas arising in an ectopic parathyroid gland are rare. We report a case of non-functioning anterior mediastinal parathyroid adenoma associated with mediastinal lymphadenopathy caused by sarcoid-like granulamatous inflammation.

The orbit is involved in 10% of all lymphomas. Paranasal sinuses and nose are other sites for extranodal lymphoma that are involved in upto 2.6 to 6.7% of lymphomas involving head and neck region and are second most common presentation of extranodal lymphoma. In nearly 22.5% of patients, sinonasal lymphoma and orbital lymphoma may coexist. The present report describes such patient with first presentation to an ophthalmologist with an attempt to review the present literature of coexistent orbital and paranasal sinuses lymphoma.