A new antibiotic armillaric acid (2), has been isolated from the cultured mycelia of Armillaria mella (Vahl. ex Fr.) Quel (Trichlometaceae). Its structure was elucidated on the basis of the spectral data. Compound 2 exhibits inhibitory activity against gram-positive bacteria and yeast.

Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridyl-methylamino)-9-beta-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra.

The continued investigation of the mycelial extract of ARMILLARIA MELLEA (Vahl.ex Fr.) Quel. (Tricholomelaceae) led to the isolation of two new sesquiterpenoid aromatic esters, named armillarigin ( 1) and armillarikin ( 2). Their structures were elucidated on the basis of spectral data and chemical transformation.

No abstract

The actions of the Chinese medicine "Hange-Koboku-To" (HK) and its component crude drugs on the laryngeal reflex, spontaneous locomotor activity and other neuropharmacological actions were studied. The extracts of HK, the barks of Magnolia obovata and aerial parts of Perillafrutescens var. acuta clearly inhibited the laryngeal reflex in cats. The ilK extract also inhibited the locomotor activity in rats, and prolonged the sleeping time induced by hexobarbital sodium in mice. These findings suggest that HK action of removing the foreign body sensation in the throat is mainly due to inhibition of the laryngeal reflex.