ABSTRAKBanyak tipe pati dari beberapa tanaman dapat digunakan sebagai alternative untuk bahan tambahan pada formulasi tablet. Salah satu sumber yang telah dikembangkan sebagai eksipien farmasi adalah pati umbi talas, yang relatif mudah ditemukan di daerah tropic seperti Indonesia. Tujuan penelitian ini adalah untuk mengetahui kemampuan serbuk umbi talas sebagai pengikat dalam pembuatan tablet parasetamol dengan konsentrasi 5%, 10%, 15%, 20% dan 25% secara granulasi basah. Pada pengujian mutu fisik tablet yang digunakan menurut Farmakope Indonesia Edisi IV yaitu Uji Kekerasan dan Uji Keregasan tablet. Kedua parameter tersebut digunakan untuk mengetahui apakah daya ikat bahan pengikat serbuk umbi talas dalam menghasilkan sediaan tablet yang baik. Hasil penelitian pada pengujian keregasan tablet menunjukkan konsentrasi 5%, 10%, 15%, 20% dan 25% tidak memenuhi syarat uji keregasan. Pada pengujian kekerasan tablet, hasil yang diperoleh pada konsentrasi 5% tidak memenuhi persyaratan karena dibawah 4 kg/cm 2 , sedangkan pada konsentrasi 10%, 15%, 20% dan 25% memenuhi syarat karena kekerasan tabletnya berkisar antara 4 kg/cm 2 -8 kg/cm 2 .

The government in responding to COVID-19 is currently carrying out the COVID-19 Vaccination program and is urging the public to continue implementing health protocols such as wearing masks even though they have been vaccinated. This study aimed to determine the level of public compliance with the use of masks after carrying out the COVID-19 vaccination. This research was conducted in one of the districts in Makassar City. This research is an observational analytic with a cross-sectional approach. The sample size is 50 respondents. Purposive sampling technique. The instruments used were data collection sheets and questionnaires to measure compliance. The results of the study found that as much as 84.0% of the public was disobedient in using masks. The results of this study concluded that most people in District "X" Makassar City were disobedient in using masks during the Covid-19 pandemic.

Penyakit diare merupakan penyakit endemis di Indonesia dan juga penyakit potensial KLB yang sering disertai dengan kematian. Penelitian ini bertujuan untuk mengidentifikasi kejadian DRPs dalam pengobatan diare pada pasien anak rawat inap di Rumah Sakit Umum Labuang Baji Makassar. Penelitian ini merupakan penelitian observasional dengan pendekatan cross sectional. Pengumpulan data dilaksanakan bulan Juni – Agustus 2017. Jumlah sampel sebanyak 27 lembar rekam medik pasien anak diare. Analisis data dilakukan secara deskriptik dalam besaran persentase kejadian DRP berdasarkan kategori.Hasil penelitian ini menemukan bahwa kejadian DRP kategori tepat obat sebesar 23,01 %, tepat dosis (subterapi dan dosis terlalu tinggi) masing-masing sebesar 73,07 % dan 3,84 %, dan tidak ditemukan DRPs pada kategori duplikasi obat dan interaksi obat. Hasil penelitian ini juga menemukan obat dengan kelas terapi antibiotik yang paling banyak mengalami DRP (38,45 %), kemudian zink 34,61 %, disusul kortikosteroid 11,50 %, dan antihistamin 7,66 %. Hasil penelitian ini menyimpulkan bahwa terjadi DRPs kategori tepat obat dan tepat dosis dengan persentase terbesar pada obat dengan kelas terapi antibiotik.Kata kunci : DRP, diare, RSUD Labuang Baji

Drug interactions are directly related to factors such as polypharmacy. Meanwhile, patients with hypertension are at high risk for potential drug interactions due to the large number and types of drugs consumed. Therefore, this research aims to determine the potential for drug interactions in hypertensive patients at one of the Makassar City General Hospitals. It also analyzed the factors with the most significant effect on the potential for drug interactions. Furthermore, this is a descriptive-analytic research with a crosssectional approach. The sample were determined using a consecutive sampling technique and the research was conducted between March-June 2020. In addition, the potential drug interactions were identified using Micromedex 2.0 software and Handbook of Drug Interaction Fact. Analysis of the factors with the most influence on potential for drug interactions was performed using multiple logistic regression statistical tests. The results showed that the number of drugs prescribed had a significant influence on the potential for drug interactions with p = 0.023, OR = 11.676 (9% CI 1.401-97.322). Based on the results, the number of drugs prescribed is the most influential factor in the potential for drug interactions.

Basil leaves and basil seeds have been shown to contain secondary metabolites such as alkaloids, flavonoids, tannins, polyphenols, essential oils that have the potential as antibacterial. Basil seeds are produced from the seeds of the basil flower. The aim of the study was to identify the chemical constituents and compare the antibacterial potential of basil leaves and flowers (Ocimum sanctum L.) against Propionibacterium acnes. Antibacterial testing method with agar diffusion disk using blank paper disc and Nutrien Agar media. Basil leaves and flowers were macerated with ethanol, then prepared as test materials for concentrations of 10, 20 and 40 mg/ml. The results showed that basil leaf extract contains alkaloids, tannins, flavonoids and polyphenols. It was concluded that basil leaves and flowers may act as antibacterial Propionibacterium acnes at concentrations of 10 mg/ml, 20 mg/ml and 40 mg ml. Basil leaves are more potent than basil flowers as an antibacterial Propionibacterium acnes with an optimal concentration of 20 mg/ml, but the amount of chemical compounds in the basil flower extract is higher.