Effects of Ethanolic Extract of Arrowroot Tubers (Maranta Arundinacea L.) on the Level of Mda, SGPT and Sgot in Ethanol Induced Rats

Antibiotics from the aminoglycoside group, such as gentamicin, are frequently used for the infection therapy of gram-negative bacteria including Salmonella typhi. Some studies show that gentamicin can cause hepatotoxicity and increase the level of SGPT (serum glutamic pyruvic transaminase). The purpose of this research is to figure out the decreasing SGPT level of male Wistar rats induced by gentamicin with the purslane ethanol extract. This research employed a post-test only control group design, utilizing 25 male Wistar rats divided into 5 groups. The normal control group (NorG) was without any treatment, while the positive control (PG) was intraperitoneally injected with gentamicin 60 mg/kg of rat body weight. The treatment groups consisted of P1, P2, and P3 were intraperitoneally injected with gentamicin at the dosage of 60 mg/kg of rat body weight for 7 days and then administered with purslane ethanol extract respectively at the dosage of 200, 300, and 400 mg/kg of rat body weight per oral for 7 days. The analysis on the SGPT level was conducted with the IFCC modification method using chemistry analyzer. One way ANOVA test shows that there were significant differences in SGPT levels among groups. LSD post hoc test shows that purslane ethanol extract at the dosage of 400 mg/kg of rat body weight significantly decreased the SGPT level (p<0.05) when compared to the positive control group. The administration of common purslane ethanol extract at the dosage of 200, 300, and 400 mg/kg of rat body weight can decrease the SGPT level of male Wistar rats induced by gentamicin.

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“…Vitamin and mineral have the function as cell maintainer by increasing phagocytosis and suppress the occurring inflammation. 9,20,30 .…”

Section: Resultsmentioning

confidence: 99%

Decreasing the SGPT level of male wistar rats induced by gentamicin with purslane ethanol extract

Saptaningtyas

Rahajoe

Nuroini

2021

J. Teknol. Laboratorium

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“…In the liver, this process causes impaired liver function. Oxidative stress compresses antioxidants [12]. Oxidative stress is a pathological condition, can cause abnormalities in the body one of the developments of liver damage.…”

Section: Examination Of Mda Sgot and Sgpt Levels In Serummentioning

confidence: 99%

Protection Effects of Nothopanax scutellarium on Hepatotoxicity of Copper(II) Induced to Experimental Rats

Nasution

Yerizel

Chaidir

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Nothopanax scutellarium is a plant containing substance such as flavonoids, saponins, amygdalin, peroxidase, calcium oxalate, polyphenols, proteins, fats, calcium, phosphorus, iron, and Vitamins A, B1, and C. AIM: The purpose of this study was to investigate the hepatoprotective effect of N. scutellarium leaves against rats induced with Cu(II). MATERIALS AND METHODS: Three groups of female Wistar rats (Rattus norvegicus) within the range of age 2.5–3 months were used. Each group was composed of three female rats. Group I was a control given a normal diet and distilled water. Group II was exposed to 1000 mg/L of Cu(II) solution with a dosage of 1 mL × bw/200 g. Group III was given 5 mL of antidote N. scutellarium extract for 7 days then exposed to 1000 mg/L of Cu(II) solution with a dosage of 1 mL × bw/200 g. The blood test (malondialdehyde [MDA], serum glutamic oxaloacetic transaminase [SGOT], and serum glutamic pyruvic transaminase [SGPT]) and histopathology of liver were examined after 5 h of exposure. RESULTS: The administration of N. scutellarium as hepatoprotective in experimental rats resulted in significant reductions in MDA, SGOT, and SGPT as much as 33.87%, 51.14 %, and 12.57 %, respectively. CONCLUSION: This study concluded that indicates the increase of the parameters of liver function and stress oxidative parameters including MDA, SGOT, and SGPT.

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“…Bunga Rosella (Hibiscus sabdariffa L.), diketahui memiliki kandungan antioksidan yang tinggi. 1,2,3 Kandungan antioksidan dalam Rosella memiliki efek pemerangkapan radikal bebas yang baik sehingga mampu melindungi sel hepatosit dari kerusakan yang disebabkan oleh peroksidasi lemak. 4,5 Stres oksidatif dianggap sebagai mekanisme patologis yang berkontribusi terhadap inisiasi dan pengembangan kerusakan hati.…”

Section: Pendahuluanunclassified

Effective Dose of Rosella Calyx Extract (Hibiscus sabdariffa L.) against Liver Marker Enzymes and Liver Histopathological of High-Fat Feed-Induced Rats

Hidayat

Adhika

Tanuwijaya

et al. 2019

JMH

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Liver disease is a disease caused by various factors that damage the liver, such as viruses, obesity and alcohol consumption. Many studies have been done to find natural remedies for this disease, one of which is Rosella. In this research, the effective dose of ethanol extract of rosella calyx (EERC) was conducted, in high-fat feed (HFF)-induced rats. The aim of this study was to determine the effective dose of EEKR based on parameters:liver histopathological, Alanine Transferase (ALT) and Gamma Glutamyl Transferase (GGT) level. The study was conducted on 30 male Wistar rats, which were divided into five treatment groups. As results, histopathological observations showed a significant decrease in cloudy swelling scores at EERC 200 mg/KgBW/d, decreased steatosis scores at doses of 200, 400, 600 mg; whereas ballooning degeneration, lobular inflammation, and fibrosis scores did not decrease. EERC 200, 400, 600 mg/KgBW/d significantly decreased ALT (p ? 0.01); while doses of 400 and 600 mg reduce GGT. Conclusions, effective dose of EEKR for liver disease based on histopathological features of liver, ALT and GGT in HFF- induced Wistar rats is dose of 200 - 400 mg /KgBW/day. Keywords: effective dose, Rosella, histopathologic, Alanine Transferase, Gamma Glutamyl Transferase

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Effects of Ethanolic Extract of Arrowroot Tubers (Maranta Arundinacea L.) on the Level of Mda, SGPT and Sgot in Ethanol Induced Rats

Cited by 13 publications

References 8 publications

Decreasing the SGPT level of male wistar rats induced by gentamicin with purslane ethanol extract

Decreasing the SGPT level of male wistar rats induced by gentamicin with purslane ethanol extract

Protection Effects of Nothopanax scutellarium on Hepatotoxicity of Copper(II) Induced to Experimental Rats

Effective Dose of Rosella Calyx Extract (Hibiscus sabdariffa L.) against Liver Marker Enzymes and Liver Histopathological of High-Fat Feed-Induced Rats

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